Hodge William G, Boivin Jean-François, Shapiro Stanley H, Shah Kirtida C, Dionne Michel A
University of Ottawa Eye Institute, Ottawa, Ontario.
Can J Ophthalmol. 2005 Dec;40(6):701-10. doi: 10.1016/s0008-4182(05)80086-9.
To determine the iatrogenic risk factors for cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS).
The case-control study included 120 patients with CMV retinitis and 159 patients without CMV retinitis, all of whom had AIDS and CD4 counts less than 50 cells/microL at the time of diagnosis of retinitis or at the defined corresponding date in the controls. Iatrogenic risk factors studied were corticosteroid use, treatment with chemotherapy, treatment with radiotherapy, and blood transfusions.
Among the risk factors studied, only steroid use was predictive of CMV retinitis (odds ratio 6.41, 95% confidence interval 2.35-17.51). Based on this study, the use of steroids systemically elevated the risk of CMV retinitis.
确定获得性免疫缺陷综合征（AIDS）患者发生巨细胞病毒（CMV）视网膜炎的医源性危险因素。
该病例对照研究纳入了120例CMV视网膜炎患者和159例无CMV视网膜炎患者，所有患者均患有AIDS，且在视网膜炎诊断时或对照组中规定的相应日期，CD4细胞计数低于50个/微升。所研究的医源性危险因素包括使用皮质类固醇、化疗、放疗和输血。
在所研究的危险因素中，只有使用类固醇可预测CMV视网膜炎（比值比6.41，95%置信区间2.35 - 17.51）。基于本研究，全身使用类固醇会增加CMV视网膜炎的风险。
