Thornburg Courtney, Pipe Steven
Department of Pediatrics, Duke University, Durham, North Carolina, USA.
Semin Fetal Neonatal Med. 2006 Jun;11(3):198-206. doi: 10.1016/j.siny.2006.01.005. Epub 2006 Mar 6.
Thrombosis risk is multifactorial, with interaction of hereditary risk factors and acquired environmental and clinical conditions. Newborns are at particular risk for thrombotic emergencies secondary to the unique properties of their hemostatic system, influences of the maternal-fetal environment, and perinatal complications and interventions. Thrombotic complications range from arterial and venous catheter thrombosis to purpura fulminans. Prompt identification and appropriate management of thrombotic emergencies is critical in avoiding limb-, organ-, and life-threatening complications. Treatment strategies have been extrapolated from adult literature but clinical experience from small-scale neonatal studies has resulted in therapeutic guidelines, which should be individualized for each neonate, taking into consideration age and clinical status.
血栓形成风险是多因素的，涉及遗传风险因素与后天环境及临床状况的相互作用。由于新生儿止血系统的独特特性、母胎环境的影响以及围产期并发症和干预措施，他们发生血栓形成紧急情况的风险尤为突出。血栓形成并发症范围从动静脉导管血栓形成到暴发性紫癜。迅速识别并妥善处理血栓形成紧急情况对于避免肢体、器官和生命威胁性并发症至关重要。治疗策略是从成人文献中推断而来，但小规模新生儿研究的临床经验已形成治疗指南，应根据每个新生儿的年龄和临床状况进行个体化治疗。
