Mazzolai L, Duchosal M A
Service of Angiology, Department of Medicine, CHUV, Lausanne University Hospital, Lausanne, Switzerland.
Eur J Vasc Endovasc Surg. 2007 Oct;34(4):483-8. doi: 10.1016/j.ejvs.2007.04.023. Epub 2007 Jun 27.
Venous thromboembolism is a complex disease resulting from the interactions of several risk factors from diverse origins: genetic, environmental and behavioral. Numerous studies have evidenced an association between genetic thrombophilia defects and venous thromboembolism. However, the clinical relevance of genetic thrombophilia to recurrent venous thromboembolism is not clear and the risks of long-term anticoagulant treatment usually outweigh any benefits of hereditary thrombophilia screening. Therefore, in everyday clinical practice (outside of research protocols) hereditary thrombophilia screening should be performed only in cases where such testing is likely to influence patient management.
静脉血栓栓塞症是一种复杂的疾病，由多种不同来源的风险因素相互作用导致：遗传、环境和行为因素。大量研究已证实遗传性血栓形成倾向缺陷与静脉血栓栓塞症之间存在关联。然而，遗传性血栓形成倾向与复发性静脉血栓栓塞症的临床相关性尚不清楚，长期抗凝治疗的风险通常超过遗传性血栓形成倾向筛查的任何益处。因此，在日常临床实践（研究方案之外）中，仅在此类检测可能影响患者管理的情况下才应进行遗传性血栓形成倾向筛查。
