Zhang Wei, Zhang Si-Zhong, A Zhou-Cun
Department of Medical Genetics/State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Yi Chuan. 2006 Feb;28(2):231-5.
Synaptonemal complex (SC) which is a meiosis-specific supramolecular proteinaceous structure plays a crucial role in condensation, pairing, recombination and disjunction of homologous chromosomes at meiosis I. In recent years,a series of new developments on SC has been made, including new findings in both component and function of SC. Abnormalities of SC resulting from genetic mutation can directly induce arrest of spermatogenesis in rat model. More importantly, in human male patients with non-obstructive infertility the fact that genetic variation of SC (e.g. SCP3) is the causative factor of idiopathic azoospermia had been confirmed, and the investigation of SCP1 is under way.
联会复合体（SC）是一种减数分裂特异性的超分子蛋白质结构，在减数第一次分裂时同源染色体的浓缩、配对、重组和分离过程中起着关键作用。近年来，关于联会复合体有一系列新进展，包括其组成成分和功能方面的新发现。在大鼠模型中，基因突变导致的联会复合体异常可直接引起精子发生停滞。更重要的是，在人类非梗阻性不育男性患者中，已证实联会复合体的基因变异（如SCP3）是特发性无精子症的致病因素，并且对SCP1的研究正在进行中。
