Sanders A M, Edwards H M
Department of Poultry Science, University of Georgia, Athens 30602.
Poult Sci. 1991 Apr;70(4):853-66. doi: 10.3382/ps.0700853.
The effect was studied of 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] at various levels of vitamin D3, with adequate or inadequate dietary calcium, on performance and bone development in turkey poults. Two experiments were conducted. Experiment 1 lasted 16 days and was a 4 x 2 factorial arrangement using a low calcium diet (.7%), with dietary levels of vitamin D3 of 450, 900, 1,800, and 3,600 ICU/kg of diet and with or without 10 micrograms of dietary 1,25-(OH)2D3. Experiment 2 lasted 14 wk and was a 2 x 2 x 2 factorial arrangement with vitamin D3 levels of 900 or 2,700 ICU/kg of diet, calcium levels at 58 or 100% of the National Research Council requirement (which varies with age), and with or without 10 micrograms/kg of dietary 1,25-(OH)2D3. In Experiment 1, increasing levels of vitamin D3 and 1,25-(OH)2D3 supplementation significantly increased bone ash. Pairwise contrasts at specific vitamin D3 levels indicated that this effect of 1,25-(OH)2D3 was greater at lower levels of vitamin D3. In Experiment 2, the 2,700-ICU level of vitamin D3 decreased the incidence of rickets at 3 wk and partially ameliorated a calcium deficiency, as indicated by an increase in growth at the 2,700-ICU level of vitamin D3 in calcium-deficient diets from 8 to 14 wk. Vitamin D3 by calcium interactions on rickets at 14 wk of age and bone ash at 3 and 14 wk were similar and indicated also that vitamin D3 partially ameliorated a calcium deficiency. In general, the addition to the diet of 1,25-(OH)2D3 increased bone ash and decreased the incidence of rickets in diets deficient in calcium but high in vitamin D3. There is very little evidence in the present study that indicates that 1,25-(OH)2D3 has any effect on tibial dyschondroplasia.
研究了在不同维生素D3水平、日粮钙充足或不足的情况下，1,25 - 二羟胆钙化醇[1,25-(OH)2D3]对火鸡雏鸡生产性能和骨骼发育的影响。进行了两项试验。试验1为期16天，采用低钙日粮（0.7%），日粮维生素D3水平分别为450、900、1800和3600国际雏鸡单位/千克日粮，添加或不添加10微克日粮1,25-(OH)2D3，为4×2析因设计。试验2为期14周，采用2×2×2析因设计，维生素D3水平为900或2700国际雏鸡单位/千克日粮，钙水平为美国国家研究委员会（随年龄变化）需求量的58%或100%，添加或不添加10微克/千克日粮1,25-(OH)2D3。在试验1中，增加维生素D3和1,25-(OH)2D3的添加量显著增加骨灰含量。在特定维生素D3水平下的成对比较表明，1,25-(OH)2D3在较低维生素D3水平时的这种作用更大。在试验2中，2700国际雏鸡单位水平的维生素D3降低了3周龄时佝偻病的发病率，并部分改善了钙缺乏状况，这表现为在8至14周龄时，钙缺乏日粮中2700国际雏鸡单位水平的维生素D3使生长增加。14周龄时维生素D3与钙对佝偻病的相互作用以及3周龄和14周龄时对骨灰含量的相互作用相似，也表明维生素D3部分改善了钙缺乏状况。总体而言，在钙缺乏但维生素D3含量高的日粮中添加1,25-(OH)2D3可增加骨灰含量并降低佝偻病发病率。本研究中几乎没有证据表明1,25-(OH)2D3对胫骨软骨发育不良有任何影响。
