2,3,7,8-四氯二苯并对二恶英通过激活相应基因的转录来诱导细胞色素P450IA1酶活性。
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene.
作者信息
Lusska A E, Jones K W, Elferink C J, Wu L, Shen E S, Wen L P, Whitlock J P
机构信息
Department of Pharmacology, Stanford University School of Medicine, CA 94305.
出版信息
Adv Enzyme Regul. 1991;31:307-17. doi: 10.1016/0065-2571(91)90019-i.
PMID:1652189
Abstract
We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.
摘要
我们已经回顾了编码细胞色素P450IA1酶的CYP1A1基因的转录调控。2,3,7,8-四氯二苯并对二恶英（TCDD）通过一种受体和增强子依赖的机制诱导CYP1A1转录，该机制涉及多种蛋白质与DNA的相互作用。该系统提供了一个在基因转录水平上进行酶调控的例子。
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