与细胞色素P1-450基因相关的二噁英反应增强子处的原位蛋白质-DNA相互作用。
In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene.
作者信息
Durrin L K, Whitlock J P
机构信息
Department of Pharmacology, Stanford University School of Medicine, California 94305.
出版信息
Mol Cell Biol. 1987 Aug;7(8):3008-11. doi: 10.1128/mcb.7.8.3008-3011.1987.
Abstract
We used an in situ exonuclease III protection technique (C. Wu, Nature [London] 309:229, 1984) to analyze protein-DNA interactions at a dioxin-responsive enhancer. Our results imply that the 2,3,7,8-tetrachlorodibenzo-p-dioxin-receptor complex interacts with the dioxin-responsive enhancer to activate transcription of the cytochrome P1-450 gene.
摘要
我们使用原位核酸外切酶III保护技术（C. 吴，《自然》[伦敦] 309:229，1984年）来分析二噁英反应增强子处的蛋白质-DNA相互作用。我们的结果表明，2,3,7,8-四氯二苯并对二噁英-受体复合物与二噁英反应增强子相互作用，以激活细胞色素P1-450基因的转录。
Zotero 插件