Manthena Prasanth, Zee Phyllis C
Department of Neurology, Northwestern University School of Medicine, 710 North Lake Shore Drive, 11th Floor, Chicago, IL 60611, USA.
Curr Neurol Neurosci Rep. 2006 Mar;6(2):163-8. doi: 10.1007/s11910-996-0040-9.
To adapt to a 24-hour environment, nearly all organisms, from mammals to single-celled organisms, have developed endogenous mechanisms that generate nearly 24-hour (circadian) rhythms in physiology and behavior, the most notable being that of the daily cycles of sleep and wake. Disruption of these circadian rhythms is often accompanied by disorders of sleep and wakefulness. With the recent advances in the molecular biology that underlies the development and maintenance of these rhythms, the pathophysiology behind circadian rhythm sleep disorders is becoming better understood.
为了适应24小时的环境，几乎所有生物，从哺乳动物到单细胞生物，都发展出了内源性机制，这些机制能在生理和行为上产生近24小时（昼夜节律）的节律，其中最显著的是睡眠和觉醒的日常周期。这些昼夜节律的紊乱通常伴随着睡眠和觉醒障碍。随着构成这些节律的发展和维持基础的分子生物学的最新进展，昼夜节律睡眠障碍背后的病理生理学正被更好地理解。
