Stang Andreas, Schmidt-Pokrzywniak Andrea, Lehnert Martin, Parkin Donald M, Ferlay Jaques, Bornfeld Norbert, Marr Anja, Jöckel Karl-Heinz
Institute of Medical Epidemiology, Biometry and Informatics, Medical Faculty, Martin-Luther-University of Halle-Wittenberg, Halle, Germany.
Eur J Cancer Prev. 2006 Apr;15(2):165-70. doi: 10.1097/01.cej.0000197453.79733.a6.
Valid incidence rates of uveal melanoma (UM) from German population-based cancer registries are currently not available due to under-reporting. We conducted two case-control studies on UM at a reference centre for eye tumours and show the influence on population-based incidences of UM when data from case-control studies are linked with a cancer registry. The first case-control study (1996-1998) recruited 13 UM cases aged 35-74 years and the second case-control study (2002-2003) recruited 20 UM cases aged 20-74 residing within the population covered by the Münster Cancer Registry. After record linkage, age-truncated and standardized (World Standard Population) incidences with and without the record linkage were compared. Incidence rates based on routine cancer registration increased by a factor of 1.7 (1996-1998, age group 35-74 years) and 3.7 (2002-2003, age group 20-74 years) after record linkage with the case-control data. The supplemented age-standardized incidence of UM is 8.6 per million (20-74 years, 2002-2003) compared with the unsupplemented incidence of 2.3 per million. UM unknown to the registry were less often morphologically verified than those known to the registry. Cancer registries relying on pathology reports underestimate UM incidences if eye-preserving treatments are introduced. Close co-operation between cancer referral centres and cancer registries can substantially improve the completeness of registration.
由于报告不足，目前无法从德国基于人群的癌症登记处获得葡萄膜黑色素瘤（UM）的有效发病率。我们在一家眼肿瘤参考中心进行了两项关于UM的病例对照研究，并展示了将病例对照研究数据与癌症登记处数据相链接时对基于人群的UM发病率的影响。第一项病例对照研究（1996 - 1998年）招募了13例年龄在35 - 74岁的UM患者，第二项病例对照研究（2002 - 2003年）招募了20例年龄在20 - 74岁、居住在明斯特癌症登记处覆盖人群内的UM患者。记录链接后，比较了有和没有记录链接情况下的年龄截断和标准化（世界标准人口）发病率。与病例对照数据进行记录链接后，基于常规癌症登记的发病率在1996 - 1998年（年龄组35 - 74岁）提高了1.7倍，在2002 - 2003年（年龄组20 - 74岁）提高了3.7倍。补充后的UM年龄标准化发病率为每百万8.6例（20 - 74岁，2002 - 2003年），而未补充的发病率为每百万2.3例。登记处未知的UM病例经形态学验证的频率低于登记处已知的病例。如果采用保眼治疗，依赖病理报告的癌症登记处会低估UM发病率。癌症转诊中心与癌症登记处之间的密切合作可大幅提高登记的完整性。
