Lasithiotakis K, Leiter U, Krüger-Krasagakis S, Tosca A, Garbe C
Melanoma Unit, Dermatology Department, Medical School of Heraklion, University of Crete, Greece.
Br J Dermatol. 2006 Jun;154(6):1123-7. doi: 10.1111/j.1365-2133.2006.07163.x.
Comparative analysis of the incidence rates and epidemiological features of cutaneous malignant melanoma (CMM) between different ethnic groups exposed to varying environmental factors is critical for consideration of the causes of CMM but can also be utilized in a public health approach to control of the disease.
To compare incidence rates and clinical features of CMM in a Greek and a central European population (central Baden-Württemberg, Germany).
Incident cases of CMM were traced in all hospitals of the island of Crete for the period 1999-2002. Age-standardized incidence rates per 100 000 inhabitants per year for the European Standard Population were calculated based on the Cretan population statistics. A comparison was performed between the Cretan findings and those of southern Germany as registered by the hospital-based Central Malignant Melanoma Registry, which likewise documents more clinical features than normally recorded by population-based cancer registries.
Mean incidence rates in Crete for 1999-2002 were 4.01 per 100 000 inhabitants per year for males and 4.05 for females as compared with 10.6 for males and 11.1 for females in southern Germany. There were striking differences in the clinical characteristics of CMMs, with significantly higher tumour thickness in Crete (median 1.4 mm vs. 0.7 mm in southern Germany). Correspondingly, significantly more nodular melanomas were observed in Crete (29%) as compared with southern Germany (11%).
Incidence of CMM in Crete, with about four cases per 100 000 inhabitants per year, is clearly higher than previously estimated, and there is an urgent necessity for earlier recognition of CMM in Crete. However, the incidence of CMM in southern Germany is much higher.
对暴露于不同环境因素的不同种族群体之间皮肤恶性黑色素瘤（CMM）的发病率和流行病学特征进行比较分析，对于探究CMM的病因至关重要，同时也可用于公共卫生层面的疾病防控。
比较希腊和中欧人群（德国巴登-符腾堡州中部）中CMM的发病率及临床特征。
追踪1999年至2002年期间克里特岛所有医院的CMM确诊病例。根据克里特岛人口统计数据，计算出欧洲标准人口每年每10万居民的年龄标准化发病率。将克里特岛的研究结果与德国南部基于医院的中央恶性黑色素瘤登记处的数据进行比较，该登记处记录的临床特征比基于人群的癌症登记处通常记录的更多。
1999年至2002年期间，克里特岛男性的平均发病率为每年每10万居民4.01例，女性为4.05例，而德国南部男性为10.6例，女性为11.1例。CMM的临床特征存在显著差异，克里特岛的肿瘤厚度明显更高（中位数为1.4毫米，而德国南部为0.7毫米）。相应地，与德国南部（11%）相比，克里特岛观察到的结节性黑色素瘤明显更多（29%）。
克里特岛CMM的发病率约为每年每10万居民4例，明显高于先前的估计，因此迫切需要在克里特岛更早地识别CMM。然而，德国南部CMM的发病率要高得多。
