使用配备容积平板的计算机断层扫描扫描仪对小鼠体内碘化血池造影剂的计算机断层扫描对比增强进行时程表征。
Time-course characterization of the computed tomography contrast enhancement of an iodinated blood-pool contrast agent in mice using a volumetric flat-panel equipped computed tomography scanner.
作者信息
Ford Nancy L, Graham Kevin C, Groom Alan C, Macdonald Ian C, Chambers Ann F, Holdsworth David W
机构信息
Imaging Research Laboratories, Robarts Research Institute; Department of Medical Biophysics, University of Western Ontario, Canada.
出版信息
Invest Radiol. 2006 Apr;41(4):384-90. doi: 10.1097/01.rli.0000197981.66537.48.
OBJECTIVE
The objective of this study was to determine the time-course of computed tomography (CT) contrast enhancement of an iodinated blood-pool contrast agent.
METHODS
Five C57BL/6 mice were anesthetized, imaged at baseline, and given an iodinated blood-pool contrast agent. Micro-CT scans were acquired at 0, 0.25, 0.5, 1, 2, 4, 8, and 24 hours after injection. The mean CT number was determined in a region of interest in 7 organs.
RESULTS
The CT contrast enhancement was plotted as a function of time for each organ. We identified an imaging window immediately after injection suitable for visualizing the vascular system and a second imaging window at 24 hours for visualizing liver and spleen.
CONCLUSIONS
A single injection of the blood-pool contrast agent can be used for dual-phase investigations of the vasculature (t = 0 hours) and liver (t = 24 hours), which can be applied to studies of liver tumors or disease.
目的
本研究的目的是确定碘化血池造影剂的计算机断层扫描（CT）增强的时间进程。
方法
对5只C57BL/6小鼠进行麻醉，在基线时成像，然后给予碘化血池造影剂。在注射后0、0.25、0.5、1、2、4、8和24小时进行微型CT扫描。在7个器官的感兴趣区域测定平均CT值。
结果
绘制每个器官的CT增强随时间变化的曲线。我们确定了注射后立即适合观察血管系统的成像窗口，以及24小时时适合观察肝脏和脾脏的第二个成像窗口。
结论
单次注射血池造影剂可用于血管系统（t = 0小时）和肝脏（t = 24小时）的双期检查，可应用于肝肿瘤或疾病的研究。
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