Kotwica J, Skarzyński D, Jaroszewski J
Department of Animal Reproduction Endocrinology, Centre for Agrotechnology and Veterinary Sciences, Olsztyn-Kortowo, Poland.
Br Vet J. 1991 May-Jun;147(3):189-96. doi: 10.1016/0007-1935(91)90043-m.
The infusion of beta-adrenomimetic drug (bamethan sulphate--BS) on day 11 of the oestrous cycle markedly increased peripheral progesterone concentration whereas infusion of beta-antagonist (propranolol) decreased plasma progesterone levels in heifers. Oxytocin injected on days 2-6 of the oestrous cycle shortened the length of the cycle (to 7-9 days) whereas the length of the cycle in heifers injected with oxytocin followed by injections of either BS or xanthinol (theophylline nicotinate--a potent vasodilatory drug) was normal (21.8 +/- 1.7). Heifers injected with BS on days 13-21 of the oestrous cycle had increased levels of progesterone on days 13-19 of the cycle and the length of the cycle was normal (22.3 +/- 0.6 compared with 21.3 +/- 1.5 for the control). The data indicate that: (1) beta-adrenergic stimulation overcomes the action of oxytocin given on days 2-6 of the cycle, whereas the stimulation of beta-receptors on days 13-21 of the oestrous cycle raised progesterone plasma concentration but did not prevent spontaneous luteolysis. (2) Basal secretion of progesterone in cattle is partly dependent on constant beta-adrenergic stimulation.
在发情周期的第11天输注β-肾上腺素能药物（硫酸巴美生——BS）可显著提高外周孕酮浓度，而在小母牛中输注β-拮抗剂（普萘洛尔）则会降低血浆孕酮水平。在发情周期的第2 - 6天注射催产素会缩短周期长度（至7 - 9天），而先注射催产素再注射BS或黄嘌呤醇（烟酸茶碱——一种强效血管舒张药物）的小母牛的周期长度正常（21.8±1.7）。在发情周期的第13 - 21天注射BS的小母牛在周期的第13 - 19天孕酮水平升高，且周期长度正常（22.3±0.6，而对照组为21.3±1.5）。数据表明：（1）β-肾上腺素能刺激可克服在周期第2 - 6天给予的催产素的作用，而在发情周期第13 - 21天对β受体的刺激可提高血浆孕酮浓度，但不能防止自发性黄体溶解。（2）牛体内孕酮的基础分泌部分依赖于持续的β-肾上腺素能刺激。
