锚定的cAMP信号传导：向前发展并不断提升——cAMP信号转导区室化的简史
Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction.
作者信息
Smith F Donelson, Scott John D
机构信息
Howard Hughes Medical Institute and Vollum Institute, Oregon Health and Sciences University, MRB 322, L474, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
出版信息
Eur J Cell Biol. 2006 Jul;85(7):585-92. doi: 10.1016/j.ejcb.2006.01.011. Epub 2006 Mar 9.
Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase anchoring proteins (AKAPs). This review discusses the history and future of anchored cAMP signaling pathways.
细胞内信号转导通路需要高度的空间和时间分辨率，以便产生适当的输出。由普遍存在的第二信使环磷酸腺苷（cAMP）及其效应物——cAMP依赖性蛋白激酶（PKA）介导的特定信号传导，受A激酶锚定蛋白（AKAPs）对不同通路组分的空间组织调控。本文综述了锚定cAMP信号通路的历史与未来。
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