Darville M I, Chikri M, Lebeau E, Hue L, Rousseau G G
Hormone and Metabolic Research Unit, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
FEBS Lett. 1991 Aug 19;288(1-2):91-4. doi: 10.1016/0014-5793(91)81009-w.
There are at least 3 isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate. A 22-kb rat gene that encodes the heart isozyme has been identified and compared with the 55-kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N- and C-termini in the 3 isozymes.
6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶至少有3种同工酶，这是一种双功能酶，可催化果糖2,6-二磷酸的合成与降解。已鉴定出一个编码心脏同工酶的22 kb大鼠基因，并将其与先前描述的编码肝脏和肌肉同工酶的55 kb大鼠基因进行了比较。尽管这两个基因包含12个连续的相似外显子，但它们两端都含有不同的外显子，这与3种同工酶的N端和C端存在不同的调节结构域相一致。
