超液态碘油的不良反应：1例意外病例报告

Adverse reactions to lipiodol ultra fluid: report of an accidental case.

作者信息

Ogihara T, Miyao H, Katoh H, Ikenaga H, Michikawa N, Ohkubo N, Kasahara M, Iyori S

机构信息

Department of Internal Medicine, Hiratsuka City Hospital, Kanagawa, Japan.

出版信息

Keio J Med. 1991 Jun;40(2):94-6. doi: 10.2302/kjm.40.94.

DOI:10.2302/kjm.40.94

PMID:1652663

Abstract

A 25-year-old Japanese woman experienced pulmonary edema, shock, encephalopathy and silent pancreatitis after hysterosalpingography using lipiodol ultra fluid, because the contrast media flowed directly into the blood stream from endometrium injured by several curettages for termination of pregnancy. Total iodine concentrations in plasma and urine decreased exponentially and their half-life was 16.12 and 13.04 days, respectively. Clear correlations were observed between the iodine concentration in plasma and the amelioration of both electroencephalogram and neuropsychic abnormalities. Adverse reactions of oil-soluble contrast media are also discussed.

摘要

一名25岁的日本女性在使用超液态碘油进行子宫输卵管造影后，出现了肺水肿、休克、脑病和无症状性胰腺炎，原因是造影剂从因多次刮宫终止妊娠而受损的子宫内膜直接流入血流。血浆和尿液中的总碘浓度呈指数下降，其半衰期分别为16.12天和13.04天。观察到血浆中的碘浓度与脑电图和神经精神异常的改善之间存在明显的相关性。还讨论了油溶性造影剂的不良反应。