Miyamoto Y, Tsujimoto T, Iwai K, Ishida K, Uchimoto R, Miyazawa T, Azuma H
Research Department, Nihon Schering K.K., Osaka, Japan.
Invest Radiol. 1995 Sep;30(9):538-43. doi: 10.1097/00004424-199509000-00005.
The authors compared the safety and pharmacokinetics of Iotrolan (water-soluble) in hysterosalpingography (HSG) with those of Lipiodol (oil-soluble).
Iotrolan and Lipiodol were administered intraperitoneally at doses of 100 mg iodine/kg to female rabbits. Retention in the body was investigated by x-ray imaging, plasma kinetics, and urinary and fecal excretion. Irritability in the abdomen was investigated by histologic examination.
Iotrolan was entirely excreted into the urine within 2 days after administration. Conversely, Lipiodol was excreted into the urine, had a half-life of 50 days, and was retained for more than 21 days in the abdomen. Iotrolan induced no inflammatory reaction in the abdomen, whereas Lipiodol induced a marked abdominal inflammatory reaction, including granuloma formation. Iotrolan had no effect on iodine concentration in the thyroid; Lipiodol increased iodine concentration significantly.
Iotrolan, which is a water-soluble and nonionic dimeric contrast medium, has potential greater safety for use in HSG than Lipiodol.
作者比较了碘曲仑（水溶性）和碘油（脂溶性）在子宫输卵管造影（HSG）中的安全性和药代动力学。
以100mg碘/千克的剂量给雌性兔子腹腔注射碘曲仑和碘油。通过X射线成像、血浆动力学以及尿液和粪便排泄来研究体内潴留情况。通过组织学检查来研究腹部的刺激性。
碘曲仑在给药后2天内完全经尿液排出。相反，碘油经尿液排出，半衰期为50天，并且在腹部潴留超过21天。碘曲仑未在腹部诱发炎症反应，而碘油诱发了明显的腹部炎症反应，包括肉芽肿形成。碘曲仑对甲状腺中的碘浓度没有影响；碘油显著增加了碘浓度。
碘曲仑作为一种水溶性非离子二聚体造影剂，在子宫输卵管造影中使用时可能比碘油具有更高的安全性。
