甲型肝炎病毒的合成肽62-75 VP3诱导病毒结合抗体
[The synthetic peptide 62-75 VP3 of the hepatitis A virus induces virus-binding antibodies].
作者信息
Kusov Iu Iu, Kazachkov Iu A, Dzagurov G K, Nastashenko T A, Kozhich A T, Gabrielian A E, Chikin L D, Ivanov V T, Balaian M S
出版信息
Vopr Virusol. 1991 Mar-Apr;36(2):114-7.
PMID:1652865
Abstract
Peptide (P6) representing amino acids 62-75 of HAV capsid protein VP3 was synthesized. Pure P6, octamer form of P6, and P6 conjugated to KLH were injected into rabbits. The sera against these preparations reacted with denaturized VP3 in immunoblotting tests; however, only anti-P6-KLH serum was capable of binding the native HAV.
摘要
合成了代表甲型肝炎病毒衣壳蛋白VP3第62至75位氨基酸的肽（P6）。将纯P6、P6的八聚体形式以及与钥孔血蓝蛋白（KLH）偶联的P6注射到兔子体内。在免疫印迹试验中，针对这些制剂的血清与变性的VP3发生反应；然而，只有抗P6-KLH血清能够结合天然甲型肝炎病毒。
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