Waxman I, Baker B, Feinstone S M, Di Bisceglie A M
Clinical Studies Section, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland.
Am J Gastroenterol. 1991 Sep;86(9):1240-2.
The sequence of serologic events in a patient with acute type C hepatitis associated with intravenous drug abuse is described. Hepatitis C virus (HCV) ribonucleic acid was detectable in serum during the acute episode of hepatitis, whereas antibody to the hepatitis C virus appeared later, after the acute illness had subsided. The patient developed chronic hepatitis with persistently elevated serum aminotransferase activities. Both hepatitis C viral ribonucleic acid and antibody to hepatitis C virus persisted in serum, together with elevated serum aminotransferases. Thus, detection of HCV RNA may be useful in the diagnosis of acute type C hepatitis, particularly in the absence of detectable antibody to the hepatitis C virus.
本文描述了一名与静脉注射毒品相关的急性丙型肝炎患者的血清学事件序列。在肝炎急性发作期间，血清中可检测到丙型肝炎病毒（HCV）核糖核酸，而丙型肝炎病毒抗体在急性疾病消退后出现得较晚。该患者发展为慢性肝炎，血清转氨酶活性持续升高。血清中丙型肝炎病毒核糖核酸和丙型肝炎病毒抗体均持续存在，同时血清转氨酶升高。因此，检测HCV RNA可能有助于急性丙型肝炎的诊断，特别是在未检测到丙型肝炎病毒抗体的情况下。
