多面体硼化合物作为潜在的诊断和治疗抗肿瘤药物。
Polyhedral boron compounds as potential diagnostic and therapeutic antitumor agents.
作者信息
Bregadze V I, Sivaev I B, Glazun S A
机构信息
A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia.
出版信息
Anticancer Agents Med Chem. 2006 Mar;6(2):75-109. doi: 10.2174/187152006776119180.
The use of polyhedral boron hydrides for cancer treatment is traditionally connected with boron neutron capture therapy. More recently, polyhedral borate anions were proposed as carriers of radionuclide label for targeted radionuclide therapy and diagnostics of cancer. Some metal derivatives of carboranes were found to demonstrate significant antitumor activity themselves. This review is designed to highlight the recent work concerning various fields of potential application of polyhedral boron compounds in anticancer diagnostics and therapy.
多面体硼氢化物用于癌症治疗传统上与硼中子俘获疗法相关。最近，多面体硼酸根阴离子被提议作为放射性核素标记的载体用于癌症的靶向放射性核素治疗和诊断。发现一些碳硼烷的金属衍生物本身就具有显著的抗肿瘤活性。这篇综述旨在突出关于多面体硼化合物在抗癌诊断和治疗中潜在应用的各个领域的近期研究工作。
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