School of Life Science, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston-upon-Thames, KT1 2EE, UK.
School of Life Science, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston-upon-Thames, KT1 2EE, UK.
Drug Discov Today. 2018 Jan;23(1):63-75. doi: 10.1016/j.drudis.2017.08.009. Epub 2017 Sep 5.
Boron neutron capture therapy (BNCT) is a promising targeted chemoradiotherapeutic technique for the management of invasive brain tumors, such as glioblastoma multiforme (GBM). A prerequisite for effective BNCT is the selective targeting of tumour cells with B-rich therapeutic moieties. To this end, polyhedral boranes, especially carboranes, have received considerable attention because they combine a high boron content with relative low toxicity and metabolic inertness. Here, we review progress in the molecular design of recently investigated carborane derivatives in light of the widely accepted performance requirements for effective BNCT.
硼中子俘获治疗（BNCT）是一种有前途的针对侵袭性脑肿瘤（如多形性胶质母细胞瘤[GBM]）的靶向化放疗技术。有效的 BNCT 的前提是用富含硼的治疗部分选择性地靶向肿瘤细胞。为此，多面体硼烷，特别是碳硼烷，受到了相当大的关注，因为它们结合了高硼含量、相对低毒性和代谢惰性。在本文中，我们根据广泛接受的有效 BNCT 的性能要求，综述了最近研究的碳硼烷衍生物的分子设计方面的进展。
