唾液腺基因治疗。

Salivary gland gene therapy.

作者信息

Cotrim Ana P, Mineshiba Fumi, Sugito Takayuki, Samuni Yuval, Baum Bruce J

机构信息

Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1190, USA.

出版信息

Dent Clin North Am. 2006 Apr;50(2):157-73, vii. doi: 10.1016/j.cden.2005.11.002.

DOI:10.1016/j.cden.2005.11.002

PMID:16530055

Abstract

Salivary glands have proven to be unusual but valuable target sites for multiple clinical gene transfer applications. Access to salivary glands for gene transfer is easy. Multiple studies in animal models have yielded proofs of concept for novel treatments for damaged salivary glands following therapeutic irraditation, in Sjögren's syndrome, and for gene therapeutics systemically by way of the blood-stream and locally in the oral cavity and upper gastrointestinal tract.

摘要

唾液腺已被证明是多种临床基因转移应用中不同寻常但很有价值的靶位点。进行基因转移时，唾液腺易于触及。在动物模型中进行的多项研究为治疗放射性损伤后的唾液腺、干燥综合征以及通过血流进行全身性基因治疗和在口腔及上消化道进行局部基因治疗的新疗法提供了概念验证。