Simmons R K, Baum B J
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
J Dent Educ. 2001 Sep;65(9):907-10.
This review provides a brief description of gene transfer studies using salivary glands as the target tissue. The aggregate results demonstrate the potential clinical value of this methodological approach for managing several conditions lacking fully satisfactory conventional treatments. Routine clinical applications are still seven to ten years away, primarily because of the need for improved gene transfer vectors. Overall, this body of work provides the dental educator with a substantive example of how biotechnological progress will significantly affect the treatment of oral problems in the near future.
本综述简要介绍了以唾液腺为靶组织的基因转移研究。总体结果表明，这种方法对于治疗几种缺乏完全令人满意的传统治疗方法的疾病具有潜在的临床价值。常规临床应用仍需7至10年时间，主要原因是需要改进基因转移载体。总体而言，这项工作为牙科教育工作者提供了一个重要的例子，说明生物技术的进步将在不久的将来如何显著影响口腔问题的治疗。
