Murray Peter E, García-Godoy Franklin
College of Dental Medicine, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USA.
Dent Clin North Am. 2006 Apr;50(2):299-315, x. doi: 10.1016/j.cden.2005.11.009.
Ideally, root canal therapy involves the removal of diseased pulp tissues and permanent replacement with healthy pulp to revitalize teeth. Rather than placing implants, the ideal solution is to grow new replacement teeth. Success rates of implants and endodontic treatments can exceed 90%, which presents a formidable challenge to tissue engineering researchers to ensure that future dental treatments are even more successful. The purpose of this article is to explain how tissue engineering can be used to create replacement teeth. The science of tissue engineering has evolved from growing simple tissues in cell culture incubators to a multistep process. Although the problems of introducing tissue engineering therapies as part of routine dental treatments are substantial, the potential benefits are equally ground breaking.
理想情况下,根管治疗包括去除病变的牙髓组织,并用健康的牙髓进行永久性替代,以使牙齿恢复活力。理想的解决方案不是植入假牙,而是长出新的替代牙齿。种植牙和牙髓治疗的成功率可以超过90%,这给组织工程研究人员带来了巨大挑战,以确保未来的牙科治疗更加成功。本文的目的是解释如何利用组织工程来制造替代牙齿。组织工程学已经从在细胞培养箱中培养简单组织发展成为一个多步骤过程。尽管将组织工程疗法作为常规牙科治疗的一部分存在诸多问题,但其潜在益处同样具有开创性。