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未来的牙科：细胞疗法应对牙齿和牙周组织的修复与再生。

Future dentistry: cell therapy meets tooth and periodontal repair and regeneration.

机构信息

Clinical and Diagnostic Sciences, Dental Institute, King's College London, London, UK.

出版信息

J Cell Mol Med. 2011 May;15(5):1054-65. doi: 10.1111/j.1582-4934.2010.01251.x.

DOI:10.1111/j.1582-4934.2010.01251.x
PMID:21199329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3822618/
Abstract

Cell-based tissue repair of the tooth and - tooth-supporting - periodontal ligament (PDL) is a new attractive approach that complements traditional restorative or surgical techniques for replacement of injured or pathologically damaged tissues. In such therapeutic approaches, stem cells and/or progenitor cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we discuss the clonogenic potential of human dental and periodontal tissues such as the dental pulp and the PDL and their potential for tooth and periodontal repair and/or regeneration. We propose novel therapeutic approaches using stem cells or progenitor cells, which are targeted to regenerate the lost dental or periodontal tissue.

摘要

基于细胞的牙齿和牙周韧带（PDL）组织修复是一种新的有吸引力的方法，它补充了传统的修复或手术技术，用于替代受伤或病理性受损的组织。在这种治疗方法中，干细胞和/或祖细胞在体外进行操作，并作为活的和动态的生物制剂给予患者。在这篇综述中，我们讨论了人牙髓和牙周组织（如牙髓和牙周韧带）的克隆形成潜力及其在牙齿和牙周修复和/或再生方面的潜力。我们提出了使用干细胞或祖细胞的新治疗方法，这些方法旨在再生丢失的牙齿或牙周组织。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/12eb562c10fc/jcmm0015-1054-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/455de715445b/jcmm0015-1054-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/d83d007d51b1/jcmm0015-1054-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/12eb562c10fc/jcmm0015-1054-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/455de715445b/jcmm0015-1054-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/d83d007d51b1/jcmm0015-1054-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82e2/3822618/12eb562c10fc/jcmm0015-1054-f3.jpg

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Future dentistry: cell therapy meets tooth and periodontal repair and regeneration.

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[3]
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Adv Healthc Mater. 2024-12

[4]
Biomaterials for Periodontal Regeneration.

Dent Clin North Am. 2022-10

[5]
Human Umbilical Cord Mesenchymal Stem Cells: Current Literature and Role in Periodontal Regeneration.

Cells. 2022-3-30

[6]
General gene expression patterns and stemness of the gingiva and dental pulp.

J Dent Sci. 2022-1

[7]
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Regen Ther. 2020-11-7

[8]
Biomimetic Aspects of Oral and Dentofacial Regeneration.

Biomimetics (Basel). 2020-10-12

[9]
Injectable Biomaterials for Dental Tissue Regeneration.

Int J Mol Sci. 2020-5-13

[10]
Periodontal Bone-Ligament-Cementum Regeneration via Scaffolds and Stem Cells.

Cells. 2019-6-4

本文引用的文献

[1]
Gingival fibroblasts as a promising source of induced pluripotent stem cells.

PLoS One. 2010-9-14

[2]
Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.

Stem Cells. 2010-10

[3]
Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars.

Bone. 2010-2-26

[4]
Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine.

Biochem Biophys Res Commun. 2010-2-6

[5]
Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues.

Stem Cells Dev. 2010-10

[6]
Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K activation-dependent manner.

J Vasc Res. 2010

[7]
Dental stem cell therapy with calcium hydroxide in dental pulp capping.

Tissue Eng Part A. 2010-6

[8]
Isolation of multipotent stem cells in human periodontal ligament using stage-specific embryonic antigen-4.

Differentiation. 2009-11-27

[9]
Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis.

J Immunol. 2009-12-15

[10]
Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes.

Eur Cell Mater. 2009-11-12

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