Cardona-Maya Wálter, López-Herrera Albeiro, Velilla-Hernández Paula, Rugeles María T, Cadavid Angela P
Reproduction Group, University of Antioquia, Medellin, Colombia.
Am J Reprod Immunol. 2006 Apr;55(4):241-5. doi: 10.1111/j.1600-0897.2005.00340.x.
In this opinion article we consider the possibility that human spermatozoa have receptors for human immunodeficiency virus-1 (HIV-1). It is clear that sperm cells have the potential for transmitting HIV-1, but the mechanisms responsible for spreading or the virus by this vector are not known. In contrast to the traditional HIV-1 target cells, spermatozoa do not express CD4 receptors or the CCR5/CXCR4 co-receptors. Recent evidence indicates that astrocytes, which also do not express these molecules, can be infected with HIV-1 through the mannose receptor. Furthermore, a 160-kDa sperm receptor that interacts with the HIV gp 120 has been described. Therefore, we hypothesize that the mannose receptor, of 165-175 kDa, is the receptor that HIV-1 uses to invade spermatozoa, which could lead to both vertical and horizontal transmission of HIV-1.
在这篇观点文章中，我们探讨了人类精子是否存在人类免疫缺陷病毒1型（HIV-1）受体的可能性。很明显，精子细胞具有传播HIV-1的潜力，但通过这种载体传播病毒的机制尚不清楚。与传统的HIV-1靶细胞不同，精子不表达CD4受体或CCR5/CXCR4共受体。最近的证据表明，同样不表达这些分子的星形胶质细胞可通过甘露糖受体感染HIV-1。此外，还描述了一种与HIV gp 120相互作用的160 kDa精子受体。因此，我们推测165 - 175 kDa的甘露糖受体是HIV-1用于侵入精子的受体，这可能导致HIV-1的垂直和水平传播。
