Eidukaite Audrone, Siaurys Almantas, Tamosiunas Vytas
Department of Molecular Immunology, Institute of Immunology, Vilnius, Lithuania.
Am J Reprod Immunol. 2006 Apr;55(4):276-81. doi: 10.1111/j.1600-0897.2005.00360.x.
Activated lymphocytes can be eliminated by Fas/Fas ligand (FasL)-induced cell death. Endometrial cells express FasL. The aim of our study was to determine the expression of CD56+ cells (natural killer and natural killer T cells) Fas antigen CD95 and the early activation molecule CD69 in the peritoneal fluid of women with endometriosis.
Two-colour flow cytometry was used.
In the early stages of endometriosis, more CD56+ cells expressed CD69 and CD95 molecules when compared with the control group. However, in case of severe endometriosis the percentage of CD95+CD56+ cells in peritoneal fluid was similar to that of the control group, but the expression of CD69 molecules remained high.
Because of Fas/FasL mechanisms, in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated, thus providing conditions for the survival of ectopic endometrial cells and the development of the disease.
活化的淋巴细胞可通过Fas/Fas配体（FasL）诱导的细胞死亡被清除。子宫内膜细胞表达FasL。我们研究的目的是确定子宫内膜异位症患者腹腔液中CD56⁺细胞（自然杀伤细胞和自然杀伤T细胞）、Fas抗原CD95和早期活化分子CD69的表达情况。
采用双色流式细胞术。
与对照组相比，在子宫内膜异位症早期，更多的CD56⁺细胞表达CD69和CD95分子。然而，在重度子宫内膜异位症患者中，腹腔液中CD95⁺CD56⁺细胞的百分比与对照组相似，但CD69分子的表达仍保持较高水平。
由于Fas/FasL机制，在子宫内膜异位症的初始阶段，活化的腹腔液CD56⁺细胞可被大量清除，从而为异位子宫内膜细胞的存活和疾病发展提供条件。
