Harder B, Bennewitz J, Reinsch N, Thaller G, Thomsen H, Kühn C, Schwerin M, Erhardt G, Förster M, Reinhardt F, Kalm E
Institut für Tierzucht und Tierhaltung, Christian-Albrechts-Universität, Kiel, Germany.
J Anim Breed Genet. 2006 Apr;123(2):89-96. doi: 10.1111/j.1439-0388.2006.00577.x.
A whole genome scan to map quantitative trait loci (QTL) for persistency of milk yield (PMY), persistency of fat yield (PFY), persistency of protein yield (PPY) and persistency of milk energy yield (PEY) was performed in a granddaughter design in the German Holstein dairy cattle population. The analysis included 16 paternal half-sib families with a total of 872 bulls. The analysis was carried out for the first lactation and for the first three lactations combined using univariate weighted multimarker regression. Controlling the false discovery rate across traits and data sets at a level of 0.15 and treating the four persistency traits as different traits revealed 27 significant QTL. A total of 12 chromosomes showed significant QTL effects on a chromosomewise basis. The DGAT1 effect was highly significant for PPY and protein yield. A haplotype analysis using results of previous studies of the same design revealed a co-segregation of various persistency QTL and QTL affecting health traits like dystocia and stillbirth and functional traits like non-return rate 90 and somatic cell score.
在德国荷斯坦奶牛群体中，采用孙女设计进行了全基因组扫描，以定位产奶量持久性（PMY）、产脂量持久性（PFY）、产蛋白量持久性（PPY）和产奶能量持久性（PEY）的数量性状位点（QTL）。分析包括16个父系半同胞家系，共有872头公牛。使用单变量加权多标记回归对第一个泌乳期以及前三个泌乳期合并进行了分析。将跨性状和数据集的错误发现率控制在0.15水平，并将四个持久性性状视为不同性状，共发现27个显著的QTL。共有12条染色体在染色体水平上显示出显著的QTL效应。DGAT1对PPY和蛋白产量的影响高度显著。利用相同设计的先前研究结果进行的单倍型分析表明，各种持久性QTL与影响难产和死产等健康性状以及90天不返情率和体细胞评分等功能性状的QTL存在共分离。
