Pieragostini E, Rubino G, Bramante G, Rullo R, Petazzi F, Caroli A
Dipartimento di Progettazione e Gestione dei Sistemi Agro-zootecnici e Forestali, Università di Bari, Italy.
J Anim Breed Genet. 2006 Apr;123(2):122-30. doi: 10.1111/j.1439-0388.2006.00566.x.
The relationship between haemoglobin polymorphism and haematological pattern were studied in Gentile di Puglia, the Apulia Merino native breed. In a sample of 292 individuals, on five different farms, alpha- and beta-globin genetic polymorphism was investigated. A remarkable polymorphism was detected especially at alpha-globin gene where the variations concerned both the quality of the gene product and gene expression. Triplicated and quadruplicated alpha-globin genes were observed in 8.6% and 1.2% of the alpha-haplotypes respectively. At beta-globin (HBB) locus, predominance of HBB(B) allele was found in all flocks, while HBB(A) overall frequency was around 11.2%. Moreover, the effect of genotypes at globin systems on haematological data was evaluated on 289 animals. A significant effect was detected for HBB locus on haematocrit (HCT) and mean corpuscular volume (MCV), with decreasing HCT and MCV for decreasing number of HBB(A) alleles in the genotype. The opposite trend was observed for mean corpuscular haemoglobin concentration. The advances presented by this paper give reasons for inferring that BB genotypes can be expected to be more resilient to climatic stress and to local parasites.
在普利亚美利奴本地品种詹蒂莱迪普利亚中研究了血红蛋白多态性与血液学模式之间的关系。在来自五个不同农场的292个个体样本中，研究了α - 和β - 珠蛋白基因多态性。检测到显著的多态性，尤其是在α - 珠蛋白基因处，其变异涉及基因产物的质量和基因表达。在8.6%和1.2%的α单倍型中分别观察到三倍体和四倍体α - 珠蛋白基因。在β - 珠蛋白（HBB）位点，所有群体中均发现HBB(B)等位基因占优势，而HBB(A)的总体频率约为11.2%。此外，在289只动物中评估了珠蛋白系统基因型对血液学数据的影响。检测到HBB位点对血细胞比容（HCT）和平均红细胞体积（MCV）有显著影响，基因型中HBB(A)等位基因数量减少时，HCT和MCV降低。平均红细胞血红蛋白浓度则呈现相反趋势。本文所呈现的进展为推断BB基因型可能更能抵御气候压力和当地寄生虫提供了依据。
