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小儿胆汁运动障碍

Biliary dyskinesia in pediatrics.

作者信息

Telega Grzegorz

机构信息

Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA.

出版信息

Curr Gastroenterol Rep. 2006 Apr;8(2):172-6. doi: 10.1007/s11894-006-0015-7.

DOI:10.1007/s11894-006-0015-7
PMID:16533482
Abstract

Biliary dyskinesia is a potential cause for acalculous biliary colic in pediatric patients. A triad of symptoms and signs, consisting of abdominal pain (with or without associated nausea or fatty food intolerance), absence of gallstones, and an abnormally low cholecystokinin-stimulated gallbladder ejection fraction is used to diagnose the disorder. In several small pediatric case series, cholecystectomy resulted in symptomatic improvement in a majority of patients with biliary dyskinesia. However, the diagnosis of biliary dyskinesia and appropriate management remain controversial. This review discusses the purported pathophysiology of biliary dyskinesia and the data available regarding diagnosis and treatment of this entity in the pediatric population.

摘要

胆囊运动障碍是小儿无结石性胆绞痛的一个潜在病因。由腹痛(伴或不伴有恶心或脂肪类食物不耐受)、无胆结石以及胆囊收缩素刺激后胆囊排空分数异常低下组成的一组症状和体征用于诊断该疾病。在几个小型儿科病例系列中,胆囊切除术使大多数胆囊运动障碍患者的症状得到改善。然而,胆囊运动障碍的诊断和恰当治疗仍存在争议。本综述讨论了胆囊运动障碍的所谓病理生理学以及有关小儿群体中该疾病诊断和治疗的现有数据。

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Biliary dyskinesia in pediatrics.小儿胆汁运动障碍
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2
Biliary dyskinesia in the pediatric patient.小儿患者的胆道运动障碍
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Outcomes of surgical therapy for biliary dyskinesia.胆囊运动障碍的手术治疗结果
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引用本文的文献

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Cholecystectomy for biliary dyskinesia: how did we get there?针对胆囊运动障碍的胆囊切除术:我们是如何走到这一步的?
Dig Dis Sci. 2014 Dec;59(12):2850-63. doi: 10.1007/s10620-014-3342-9. Epub 2014 Sep 6.
3
Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin?儿童胆汁功能不良与有症状的胆囊结石病:同一枚硬币的两面?

本文引用的文献

1
Correlation between gene expression of CCK-A receptor and emptying dysfunction of the gallbladder in patients with gallstones and diabetes mellitus.胆囊结石合并糖尿病患者胆囊CCK-A受体基因表达与胆囊排空功能障碍的相关性
Hepatobiliary Pancreat Dis Int. 2005 May;4(2):295-8.
2
Decisions in diagnosing and managing chronic gastroesophageal reflux disease in children.儿童慢性胃食管反流病的诊断与管理决策
J Pediatr. 2005 Mar;146(3 Suppl):S3-12. doi: 10.1016/j.jpeds.2004.11.034.
3
Biliary dyskinesia: a potentially unrecognized cause of abdominal pain in children.
Dig Dis Sci. 2014 Jun;59(6):1307-15. doi: 10.1007/s10620-014-3126-2. Epub 2014 Apr 9.
胆囊运动障碍:儿童腹痛一个可能未被认识到的病因。
Pediatr Surg Int. 2004 Aug;20(8):579-81. doi: 10.1007/s00383-004-1234-3. Epub 2004 Aug 18.
4
Predictors of successful outcome after cholecystectomy for biliary dyskinesia.胆囊动力障碍行胆囊切除术后成功预后的预测因素。
J Pediatr Surg. 2004 Jun;39(6):813-6; discussion 813-6. doi: 10.1016/j.jpedsurg.2004.02.017.
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Scintigraphic sign of functional biliary obstruction is pathognomic for sphincter of Oddi dysfunction.功能性胆管梗阻的闪烁造影征象是Oddi括约肌功能障碍的特征性表现。
Hepatogastroenterology. 2004 Jan-Feb;51(55):76-81.
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Biliary dyskinesia: is the problem with Oddi?胆囊运动障碍:是奥狄括约肌的问题吗?
Pediatr Surg Int. 2004 Feb;20(2):83-6. doi: 10.1007/s00383-003-1092-4. Epub 2004 Feb 10.
7
Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis.用脂肪餐(Lipomul)刺激以评估慢性非结石性胆囊炎患儿的胆囊排空情况。
J Pediatr Gastroenterol Nutr. 2003 Aug;37(2):178-82. doi: 10.1097/00005176-200308000-00017.
8
Gallbladder ejection fraction and symptom outcome in patients with acalculous biliary-like pain.无结石性胆绞痛样疼痛患者的胆囊排空分数与症状转归
Dig Dis Sci. 2003 May;48(5):890-7. doi: 10.1023/a:1023039310574.
9
Biliary dyskinesia in children.儿童胆汁运动障碍
Pediatr Surg Int. 2002 Sep;18(5-6):357-60. doi: 10.1007/s00383-002-0822-3. Epub 2002 Apr 24.
10
The effect of stress on gastric emptying rate measured with a radionuclide tracer.应激对用放射性核素示踪剂测量的胃排空率的影响。
Hepatogastroenterology. 2002 Sep-Oct;49(47):1457-60.