McGowan Jane E, Perlman Jeffrey M
Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Clin Perinatol. 2006 Mar;33(1):183-96, x. doi: 10.1016/j.clp.2005.11.007.
Hypoxic-ischemic encephalopathy remains a major cause of morbidity and mortality in preterm and full-term infants. Experimental data from animal studies suggest that interventions that improve survival of injured neurons and prevent delayed neuronal loss may decrease hypoxic ischemic brain injury. Considerable attention has focused on optimizing management of newborns in the period immediately after resuscitation from perinatal asphyxia to minimize delayed neuronal death. The evidence regarding the role of glucose in modifying post-asphyxia brain injury and resuscitation was reviewed to better define optimal glucose management after perinatal asphyxia and resuscitation.
缺氧缺血性脑病仍然是早产和足月婴儿发病和死亡的主要原因。动物研究的实验数据表明，改善受损神经元存活并预防延迟性神经元丢失的干预措施可能会减少缺氧缺血性脑损伤。相当多的注意力集中在优化围产期窒息复苏后立即对新生儿的管理，以尽量减少延迟性神经元死亡。对葡萄糖在改善窒息后脑损伤和复苏中的作用的证据进行了综述，以更好地确定围产期窒息和复苏后的最佳葡萄糖管理。
