Camacho Alvaro, Ng Bernardo
Sun Valley Behavioral Medical Center & Imperial County Behavioral Health Department of Psychiatry, University of California, San Diego, CA, USA.
J Psychopharmacol. 2006 Sep;20(5):687-9. doi: 10.1177/0269881106063134. Epub 2006 Mar 13.
Interferon-Alpha (IFN) has been effective in the treatment of chronic viral infections and cancer albeit the added risk of severe depression. The literature has reported effectiveness in the use of antidepressants for interferon-induced depression. We report a case of severe protracted depression induced by IFN in a patient diagnosed with melanoma who responded rapidly to a course of methylphenidate using the Hamilton Depressive Rating Scale. Methylphenidate appeared to be effective in the treatment of neurovegetative symptoms of major depression induced by IFN. This report provides further clinical evidence that the neurovegetative symptoms of depression might respond better to a norepinephrine uptake inhibitor or psycho-stimulants.
α干扰素（IFN）在治疗慢性病毒感染和癌症方面一直有效，尽管存在导致严重抑郁症的额外风险。文献报道了使用抗抑郁药治疗干扰素诱导的抑郁症的有效性。我们报告了一例被诊断为黑色素瘤的患者，因IFN诱导出现严重的持续性抑郁症，使用汉密尔顿抑郁量表评估发现，该患者对哌甲酯疗程反应迅速。哌甲酯似乎对治疗IFN诱导的重度抑郁症的神经植物性症状有效。本报告提供了进一步的临床证据，表明抑郁症的神经植物性症状可能对去甲肾上腺素摄取抑制剂或精神兴奋剂反应更好。
