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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Psychiatry, University of Michigan, Ann Arbor, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Jul;20(5):815-24. doi: 10.1016/0278-5846(96)00061-9.

Depressed patients who acutely improve after taking a stimulant drug have a better eventual response to chronic antidepressant treatment than do stimulant non-responders. Unlike the stimulants and most antidepressants, trazodone (TRZ) is not a potent monoamine reuptake inhibitor. 2. The authors tested the hypothesis that acute methylphenidate (MPH) and d-amphetamine (d-AMP) response would not correlate with eventual trazodone response because its site of action was different from other antidepressants. 3. It was found that acute MPH-induced improvement correlated with eventual TRZ-induced improvement to a limited degree. 4. This correlation might reflect serotonin reuptake inhibition by trazodone and suggests that this effect is therapeutically relevant.

服用兴奋剂药物后病情急性改善的抑郁症患者，最终对慢性抗抑郁治疗的反应比兴奋剂无反应者更好。与兴奋剂和大多数抗抑郁药不同，曲唑酮（TRZ）不是强效单胺再摄取抑制剂。2. 作者检验了这样一种假设，即急性哌甲酯（MPH）和右旋苯丙胺（d-AMP）反应与最终的曲唑酮反应不相关，因为其作用部位与其他抗抑郁药不同。3. 研究发现，急性MPH诱导的改善与最终TRZ诱导的改善在一定程度上相关。4. 这种相关性可能反映了曲唑酮对血清素再摄取的抑制作用，并表明这种作用具有治疗相关性。

Department of Psychiatry, University of Michigan, Ann Arbor, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Jul;20(5):815-24. doi: 10.1016/0278-5846(96)00061-9.

Depressed patients who acutely improve after taking a stimulant drug have a better eventual response to chronic antidepressant treatment than do stimulant non-responders. Unlike the stimulants and most antidepressants, trazodone (TRZ) is not a potent monoamine reuptake inhibitor. 2. The authors tested the hypothesis that acute methylphenidate (MPH) and d-amphetamine (d-AMP) response would not correlate with eventual trazodone response because its site of action was different from other antidepressants. 3. It was found that acute MPH-induced improvement correlated with eventual TRZ-induced improvement to a limited degree. 4. This correlation might reflect serotonin reuptake inhibition by trazodone and suggests that this effect is therapeutically relevant.

服用兴奋剂药物后病情急性改善的抑郁症患者，最终对慢性抗抑郁治疗的反应比兴奋剂无反应者更好。与兴奋剂和大多数抗抑郁药不同，曲唑酮（TRZ）不是强效单胺再摄取抑制剂。2. 作者检验了这样一种假设，即急性哌甲酯（MPH）和右旋苯丙胺（d-AMP）反应与最终的曲唑酮反应不相关，因为其作用部位与其他抗抑郁药不同。3. 研究发现，急性MPH诱导的改善与最终TRZ诱导的改善在一定程度上相关。4. 这种相关性可能反映了曲唑酮对血清素再摄取的抑制作用，并表明这种作用具有治疗相关性。