Fujimoto J, Okamoto E, Yamanaka N, Oriyama T, Furukawa K, Kawamura E, Tanaka T
First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Nihon Geka Gakkai Zasshi. 1991 Jul;92(7):825-30.
Experimental data of autotransfusion in hepatectomy for hepatocellular carcinoma and clinical data from forty-eight patients were analyzed. By a density gradient medium, cancer cells banded at a lower density (1.056 g/ml: mean) than red blood cells (1.105 g/ml: mean). The centrifuge autotransfusor separated the red blood cells from cancer cells and all sections of cell blocks of the blood harvested intraoperatively in 20 cases revealed no malignant cells. The average requirement of bank blood was significantly reduced in these patients than in patients without autotransfusion during one year before, 1573 ml to 478 ml (whole blood of concentrated red blood cells) (p less than 0.05). These findings indicate that autotransfusion in hepatectomy for hepatocellular carcinoma is safe and practical.
分析了肝细胞癌肝切除术中自体输血的实验数据以及48例患者的临床数据。通过密度梯度介质,癌细胞聚集在比红细胞更低的密度(平均1.056 g/ml)处(红细胞平均密度为1.105 g/ml)。离心式自体输血器将红细胞与癌细胞分离,20例术中采集血液的细胞块所有切片均未发现恶性细胞。与术前一年未进行自体输血的患者相比,这些患者库血的平均需求量显著降低,从1573 ml降至478 ml(全血或浓缩红细胞)(p<0.05)。这些发现表明,肝细胞癌肝切除术中的自体输血是安全可行的。