Bosch Martina M, Wichmann Werner W, Boltshauser Eugen, Landau Klara
Department of Ophthalmology, University Hospital Zurich, Switzerland.
Arch Ophthalmol. 2006 Mar;124(3):379-85. doi: 10.1001/archopht.124.3.379.
To determine the prevalence of optic nerve sheath meningiomas (ONSMs) in patients with neurofibromatosis type 2 (NF2).
An observational retrospective case series of 30 consecutive patients with NF2 referred to an academic ophthalmology unit from November 1, 1991, through August 31, 2003. Twenty-six patients were followed up for a mean of 93 months (range, 3-150 months). One individual was lost to follow-up, and 3 had been referred recently. Diagnosis of ONSM was made based on typical neuroradiologic and clinical features in 7 patients and on histologic criteria in 1.
Eight of 30 patients harbored unilateral (n = 6) or bilateral (n = 2) ONSMs. Six ONSMs were diagnosed at initial examination, and 4 during follow-up.
There is a strong association between ONSMs and NF2 that parallels the well-known association of optic nerve gliomas with NF1. Physicians should be aware of the possibility that patients with ONSMs may also have NF2.
确定2型神经纤维瘤病（NF2）患者中视神经鞘膜瘤（ONSM）的患病率。
一项观察性回顾性病例系列研究，纳入了1991年11月1日至2003年8月31日期间连续转诊至一家学术眼科单位的30例NF2患者。26例患者接受了平均93个月（范围3 - 150个月）的随访。1例失访，3例为近期转诊患者。7例患者根据典型的神经影像学和临床特征诊断为ONSM，1例根据组织学标准诊断。
30例患者中有8例患有单侧（n = 6）或双侧（n = 2）ONSM。6例ONSM在初次检查时被诊断，4例在随访期间被诊断。
ONSM与NF2之间存在密切关联，这与视神经胶质瘤与NF1之间的众所周知的关联相似。医生应意识到患有ONSM的患者也可能患有NF2的可能性。
