遗传表观遗传变异——重新审视软遗传。

Inherited epigenetic variation--revisiting soft inheritance.

作者信息

Richards Eric J

机构信息

Department of Biology, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA.

出版信息

Nat Rev Genet. 2006 May;7(5):395-401. doi: 10.1038/nrg1834.

DOI:10.1038/nrg1834

PMID:16534512

Abstract

Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?

摘要

传统上，表型变异被解析为由遗传变异和环境变异主导的组成部分。这两个组成部分之间的界限因可遗传的表观遗传变异而变得模糊，这种变异可能对环境输入敏感。基于染色质和DNA甲基化的机制在遗传控制与环境的界面介导了一个半独立的表观遗传遗传系统。可遗传的表观遗传变异的存在是否应该改变我们对进化变化的看法？