利用根癌农杆菌中的 d-海因酶作为生物催化剂立体选择性制备兴奋性氨基酸拮抗剂。
Stereospecific Preparation of an Excitatory Amino Acid Antagonist with d-Hydantoinase from Agrobacterium tumefaciens as a Biocatalyst.
出版信息
Appl Environ Microbiol. 1996 Feb;62(2):739-42. doi: 10.1128/aem.62.2.739-742.1996.
Abstract
Extracts of Agrobacterium tumefaciens were used to mediate the stereospecific conversion of a racemic hydantoin to a carbamyl d-amino acid derivative, which is a precursor to (2R,4R,5S)-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (ACPA). ACPA has therapeutic value as an excitatory amino acid antagonist.
摘要
根癌农杆菌提取物被用于介导消旋海因立体特异性转化为氨甲酰基-d-氨基酸衍生物，后者是(2R,4R,5S)-2-氨基-4,5-(1,2-环己基)-7-膦酸庚酸(ACPA)的前体。ACPA 作为一种兴奋性氨基酸拮抗剂具有治疗价值。
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