Sommer S E, Emanuel D, Groeger J S, Carlon G C
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York.
Chest. 1991 Sep;100(3):856-8. doi: 10.1378/chest.100.3.856.
We report a case of severe respiratory failure due to cytomegalovirus pneumonitis in a patient who underwent an allogeneic bone marrow transplant, who was successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin. We also reviewed the rationale for the use of combination therapy with an antiviral agent and immunotherapy. Because of the bone marrow toxicity of ganciclovir, an aggressive diagnostic approach, including bronchoalveolar lavage and open lung biopsy, may be necessary to establish a definitive diagnosis prior to institution of therapy.
我们报告了一例接受异基因骨髓移植的患者因巨细胞病毒肺炎导致严重呼吸衰竭的病例，该患者通过更昔洛韦与大剂量静脉注射免疫球蛋白联合治疗获得成功。我们还回顾了使用抗病毒药物与免疫疗法联合治疗的理论依据。由于更昔洛韦具有骨髓毒性，在开始治疗前，可能需要采取积极的诊断方法，包括支气管肺泡灌洗和开胸肺活检，以明确诊断。
