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物质使用障碍的遗传学概述。

An overview of the genetics of substance use disorders.

作者信息

Lachman H M

机构信息

Albert Einstein College of Medicine, Departments of Medicine and Psychiatry, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

出版信息

Curr Psychiatry Rep. 2006 Apr;8(2):133-43. doi: 10.1007/s11920-006-0013-3.

DOI:10.1007/s11920-006-0013-3
PMID:16539891
Abstract

Twin, family, and adoption studies show that genetic factors play a significant role in vulnerability to becoming addicted to drugs. Through a combination of genetic approaches, the variant alleles responsible for interindividual differences in susceptibility to addiction are being uncovered.

摘要

双胞胎、家族和领养研究表明，遗传因素在对药物成瘾的易感性中起重要作用。通过多种遗传方法的结合，正在揭示导致个体对成瘾易感性差异的变异等位基因。

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本文引用的文献

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A functional prodynorphin promoter polymorphism and opioid dependence.
Psychiatr Genet. 2005 Dec;15(4):295-8. doi: 10.1097/00041444-200512000-00013.
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Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations.混合匹配病例对照研究：混合人群中基因关联研究的实用方法。
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Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction.遗传对冲动性、冒险行为、应激反应以及药物滥用和成瘾易感性的影响。
多巴胺受体基因多态性与阿片类药物成瘾易感性的心理人格特质的关联。
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The genetics of substance dependence.物质依赖的遗传学研究。
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Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.G 蛋白信号转导调节因子 17 基因（RGS17）的变异与多种物质依赖诊断有关。
Behav Brain Funct. 2012 May 16;8:23. doi: 10.1186/1744-9081-8-23.
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Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats.延长_access 海洛因自我给药中 Lewis 和 Fischer 大鼠的剂量递增和剂量偏好。
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