Public Institute for Alcoholism and Substance Abuse Sarajevo, Bolnička 25, 71000 Sarajevo, Bosnia and Herzegovina.
Bosn J Basic Med Sci. 2013 Aug;13(3):158-62. doi: 10.17305/bjbms.2013.2355.
There is a clear evidence that same psychoactive substance may cause various individual physiological reactions in same environmental conditions. Although there is a general attitude on equal liability to opioid addiction, latest genetic analysis findings imply there are certain quantifiable factors that could lead to elevated individual liability towards development of opioid addiction. The goal of this study was to investigate association of certain personality traits and genetic factors (separately and in combination) with heroin addiction. Total of 200 individuals participated in the study: 100 patients on Metadone Maintenance Treatment (MMT) and 100 age and sex matched healthy volunteers. All were medically examined, interviewed and psychologically evaluated using Eysenck personality questionnaire (EPQ) and genotyped for DRD2 (rs1800497) using PCR-RFLP method. Overrepresentation of certain personality traits (neuroticism, psychoticism and extraversion/ intraversion), together with environemental risk factors such as: upbringing within incomplete families and familial history of psychotropic substances abuse, are associated with high-risk development of opioid addiction.
有明确的证据表明，相同的精神活性物质在相同的环境条件下可能引起不同个体的生理反应。尽管人们普遍认为对阿片类药物成瘾的责任是平等的，但最新的遗传分析结果表明，存在某些可量化的因素可能导致个体对阿片类药物成瘾的易感性增加。本研究的目的是调查某些人格特征和遗传因素（单独和组合）与海洛因成瘾的关联。共有 200 人参与了这项研究：100 名美沙酮维持治疗（MMT）患者和 100 名年龄和性别匹配的健康志愿者。所有参与者都接受了医学检查、访谈和心理评估，使用艾森克人格问卷（EPQ）进行评估，并使用 PCR-RFLP 方法对 DRD2（rs1800497）进行基因分型。某些人格特征（神经质、精神病和外向/内向）的过度表现，以及不良的成长环境，如不完整的家庭和精神活性物质滥用的家族史，与阿片类药物成瘾的高风险发展有关。
