古巴哮喘患者对屋尘螨、嗜卷尘螨和热带鳞螨皮肤试验的相关性

Correlation between skin tests to Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis in Cuban asthmatics.

作者信息

Castro Almarales R L, Mateo Morejón M, Naranjo Robalino R M, Navarro Viltre B I, Alvarez Castelló M, Ronquillo Díaz M, García Gómez I, Oliva Díaz Y, González León M, Rodríguez Canosa J S, Labrada Rosado A

机构信息

Allergens Department, National Center of Bioproducts (BIOCEN), Havana, Cuba.

出版信息

Allergol Immunopathol (Madr). 2006 Jan-Feb;34(1):23-6. doi: 10.1157/13084223.

DOI:10.1157/13084223

PMID:16540067

Abstract

BACKGROUND

Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis are the most important allergenic mites in Cuba. The aim of this study was to determine the degree of polysensitization and correlation of the skin prick test (SPT) reaction size to these mites in asthmatic patients.

METHODS

A total of 232 adult patients with asthmatic symptoms caused by house dust and positive SPT to at least one mite were included. Standardized allergenic extracts were used in SPT.

RESULTS

A total of 88.4% of patients were positive to D. siboney, 87.1% to D. pteronyssinus, and 68.1% to B. tropicalis. Sensitization to Dermatophagoides species was predominant, demonstrated by the fact that 31.9% of patients showed positive SPT to either D. siboney or D. pteronyssinus only, whereas only 5.6% was sensitized solely to B. tropicalis. Nevertheless, most patients (58.6%) were polysensitized to the 3 species. The mean wheal size produced by the different allergens in positive patients was similar (n.s. p > 0.05). Reaction size was strongly correlated (r = 0.71, p = 5.3 x 10-09) between D. siboney and D. pteronyssinus, whereas no significant correlation was found between D. pteronyssinus or D. siboney and B. tropicalis.

CONCLUSIONS

The results of this study support the need to include the 3 allergens in diagnostic panels and for combined allergen-specific immunotherapy.

摘要

背景

在古巴，粉尘螨、斯氏嗜皮螨和热带无爪螨是最重要的变应原性螨类。本研究旨在确定哮喘患者对这些螨类的多敏化程度以及皮肤点刺试验（SPT）反应大小之间的相关性。

方法

纳入232例有屋尘引起的哮喘症状且对至少一种螨类SPT呈阳性的成年患者。SPT使用标准化变应原提取物。

结果

总共88.4%的患者对斯氏嗜皮螨呈阳性，87.1%对粉尘螨呈阳性，68.1%对热带无爪螨呈阳性。对嗜皮螨属的致敏占主导，31.9%的患者仅对斯氏嗜皮螨或粉尘螨SPT呈阳性，而仅5.6%的患者仅对热带无爪螨致敏。然而，大多数患者（58.6%）对这3种螨类均呈多敏化。阳性患者中不同变应原产生的平均风团大小相似（无统计学差异，p>0.05）。斯氏嗜皮螨和粉尘螨之间的反应大小呈强相关（r = 0.71，p = 5.3×10 - 09），而粉尘螨或斯氏嗜皮螨与热带无爪螨之间未发现显著相关性。