Ferrándiz R, Casas R, Dreborg S, Einarsson R, Fernández B
Department of Allergens, National Center for Bioproducts, Havana, Cuba.
Clin Exp Allergy. 1995 Oct;25(10):929-34. doi: 10.1111/j.1365-2222.1995.tb00394.x.
The role of Pyroglyphid mites in IgE-mediated sensitization has been well established. Although mites belonging to the genus Dermatophagoides dominate in the acarofauna of domestic dust, non-pyroglyphid mites might also be of clinical importance. In Cuba, Dermatophagoides siboney is found in dust coexisting with D. pteronyssinus and Blomia tropicalis. Dermatophagoides farinae is not found. Storage mites, such as Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae, might also be present.
The aim of this study was to investigate the allergenic relationships among the mites present in the environment of allergic patients in Cuba.
The crossreactivity between an extract of D. siboney and the above mentioned six mites was studied by specific IgE inhibition, using sera of mite-sensitive patients after incubation with serial dilutions of D. siboney.
The inhibitory effect of D. siboney extract was more pronounced against D. farinae, 91%, than against D. pteronyssinus, 62%. Specific IgE to B. tropicalis, A. siro, L. destructor and T. putrescentiae were inhibited to a much lesser extent, i.e. between 47 and 58%. The correlation between IgE to D. siboney and IgE to D. pteronyssinus and D. farinae was of 0.92 and 0.90, respectively. A weaker correlation was found between D. siboney and L. destructor (0.7), A. siro (0.67), B. tropicalis (0.54) and T. putrescentiae (0.51).
Thus, D. siboney seems to be most closely related to D. farinae.
粉尘螨在IgE介导的致敏反应中的作用已得到充分证实。尽管在家庭灰尘的螨类区系中，粉尘螨属的螨类占主导地位，但非粉尘螨类也可能具有临床意义。在古巴，发现斯氏粉尘螨存在于与屋尘螨和热带无爪螨共存的灰尘中。未发现粉螨。仓储螨类，如腐食酪螨、害嗜鳞螨和家食甜螨也可能存在。
本研究旨在调查古巴过敏患者环境中存在的螨类之间的变应原关系。
使用对螨敏感患者的血清，在与斯氏粉尘螨系列稀释液孵育后，通过特异性IgE抑制研究斯氏粉尘螨提取物与上述六种螨之间的交叉反应性。
斯氏粉尘螨提取物对粉螨的抑制作用比对屋尘螨更明显，分别为91%和62%。对热带无爪螨、腐食酪螨、害嗜鳞螨和家食甜螨的特异性IgE抑制程度要小得多，即在47%至58%之间。斯氏粉尘螨IgE与屋尘螨IgE和粉螨IgE之间的相关性分别为0.92和0.90。斯氏粉尘螨与害嗜鳞螨（0.7）、腐食酪螨（0.67）、热带无爪螨（0.54）和家食甜螨（0.51）之间的相关性较弱。
因此，斯氏粉尘螨似乎与粉螨关系最为密切。
