Cimador M, Carta M, Di Pace M R, Natalè G, Castiglione A, Sergio M, Corsello G, De Grazia E
Pediatric Surgery Unit, University of Palermo, Palermo, Italy.
Minerva Pediatr. 2006 Feb;58(1):9-13.
The aim of this study was to assess the impact of postoperative morbidity during a long-term follow-up (6-12 years) in children with esophageal atresia treated at birth by primary anastomosis.
Fifteen children with esophageal atresia and tracheoesophageal fistula were surgically treated at birth and their follow-up was extended to at least 6 up to 12 years. Data included clinical examination, evaluation of nutritional habit, continuous video recording of barium esophagogram, esophageal manometry, 24-h esophageal pH-monitoring and esophageal endoscopy.
All the 15 patients completed the clinical evaluation and the set of tests. In the first 6 years, mild dysphagia and gastroesophageal reflux (GER) was observed in 3 cases whereas GER without dysphagia in 4 cases. These 7 patients were informed about simple nutritional behaviours to minimize symptoms and treated with H2-blockers. At long-term twelve-year analysis, all patients were between 50 degrees and 75 degrees percentile of expected growth. It was not referred peculiar food restrictions. Five patients showed mild dysphagia with solid foods; early satiety, epigastric burning and regurgitation were less frequent. Furthermore they showed multiple non-peristaltic body contractions at esophagogram and moderate impairment of esophageal motility at esophageal manometry. The 24-h esophageal pH-monitoring showed normal patterns in all patients. No major lesions of esophageal mucosa were detected at esophagoscopy.
Although GER and esophageal dysmotility are reported as frequent findings in patients who underwent primary repair for esophageal atresia, these disorders don't cause any relevant impairment to the quality of their nutritional habit.
本研究旨在评估出生时接受一期吻合术治疗的食管闭锁患儿在长期随访(6 - 12年)期间术后发病情况的影响。
15例食管闭锁合并气管食管瘘患儿在出生时接受了手术治疗,随访时间延长至至少6年至12年。数据包括临床检查、营养习惯评估、食管钡餐造影连续视频记录、食管测压、24小时食管pH监测和食管内镜检查。
15例患者均完成了临床评估和各项检查。在最初6年中,3例患者出现轻度吞咽困难和胃食管反流(GER),4例患者出现无吞咽困难的GER。这7例患者被告知简单的营养行为以减轻症状,并接受了H2受体阻滞剂治疗。在12年的长期分析中,所有患者的生长发育均处于预期生长曲线的50%至75%之间。未提及特殊的饮食限制。5例患者在进食固体食物时出现轻度吞咽困难;早饱、上腹部烧灼感和反流较少见。此外,他们在食管造影中显示出多次非蠕动性体部收缩,食管测压显示食管动力中度受损。24小时食管pH监测显示所有患者的模式正常。食管内镜检查未发现食管黏膜的重大病变。
尽管GER和食管动力障碍在接受食管闭锁一期修复术的患者中是常见的发现,但这些疾病并未对其营养习惯质量造成任何相关损害。