[系统性红斑狼疮中的凋亡标记酶聚（ADP - 核糖）聚合酶（PARP）]

[The apoptosis marker enzyme poly-(ADP-ribose) polymerase (PARP) in systemic lupus erythematosus].

作者信息

Böhm I

机构信息

Radiologische Universitätsklinik der Rheinischen Friedrich-Wilhelms Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn.

出版信息

Z Rheumatol. 2006 Oct;65(6):541-4. doi: 10.1007/s00393-006-0045-4.

DOI:10.1007/s00393-006-0045-4

PMID:16541210

Abstract

The enzyme poly-(ADP-ribose) polymerase (PARP) is localized within the cell nucleus and catalyzes DNA-repair. During programmed cell death (apoptosis), PARP is enzymatically cleaved. Detection of the cleavage products is characteristic for apoptosis. In patients with systemic lupus erythematosus (SLE), the highly ordered signal transduction cascade of apoptosis is disturbed. SLE patients show reduced PARP activity . PARP cleavage products are mainly found in association with either antinuclear and/or anti-dsDNA antibodies. In addition, serum samples from SLE patients and other autoimmune diseases display anti-PAR and anti-PARP autoantibodies.

摘要

聚（ADP - 核糖）聚合酶（PARP）定位于细胞核内，催化DNA修复。在程序性细胞死亡（凋亡）过程中，PARP会被酶切。检测其切割产物是凋亡的特征。在系统性红斑狼疮（SLE）患者中，高度有序的凋亡信号转导级联受到干扰。SLE患者的PARP活性降低。PARP切割产物主要与抗核抗体和/或抗双链DNA抗体相关。此外，SLE患者和其他自身免疫性疾病患者的血清样本中存在抗PAR和抗PARP自身抗体。