Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065-4805, USA.
J Interferon Cytokine Res. 2010 Mar;30(3):113-22. doi: 10.1089/jir.2010.0004.
Apoptosis and the rapid clearance of apoptotic cells (ACs) by professional or nonprofessional phagocytes are normal and coordinated processes that ensure controlled cell growth and stress response with nonpathological outcomes. Uptake of ACs by phagocytes is thought to suppress autoimmune responses through the release of anti-inflammatory cytokines such as interleukin-10 (IL-10), transforming growth factor-beta (TGF-beta), and inhibition of proinflammatory cytokines. The production of pro- and anti-inflammatory cytokines by phagocytes is highly regulated as part of an intrinsic mechanism to prevent inflammatory and autoimmune reactions in a physiological state. Production of IL-10 by phagocytes during clearance of ACs is critical to ensuring cellular homeostasis and suppression of autoimmunity. The molecular mechanism whereby IL-10 production is induced by ACs is only beginning to be understood. This review summarizes our recent work in this aspect of an essential physiological and homeostatic process.
细胞凋亡和专业或非专业吞噬细胞对凋亡细胞 (ACs) 的快速清除是正常且协调的过程，可确保细胞生长和应激反应受到控制，不会导致病理性结果。吞噬细胞摄取 ACs 被认为通过释放抗炎细胞因子（如白细胞介素 10 (IL-10)、转化生长因子-β (TGF-β)）来抑制自身免疫反应，并抑制促炎细胞因子。吞噬细胞产生促炎和抗炎细胞因子受到高度调节，这是一种内在机制的一部分，可防止在生理状态下发生炎症和自身免疫反应。吞噬细胞在清除 ACs 过程中产生 IL-10 对于确保细胞内稳态和抑制自身免疫至关重要。吞噬细胞被 AC 诱导产生 IL-10 的分子机制才刚刚开始被理解。这篇综述总结了我们在这个重要生理和内稳态过程的这一方面的最新工作。
