吞噬凋亡细胞的巨噬细胞中白细胞介素-10 基因表达的调控。
Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells.
机构信息
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065-4805, USA.
出版信息
J Interferon Cytokine Res. 2010 Mar;30(3):113-22. doi: 10.1089/jir.2010.0004.
Abstract
Apoptosis and the rapid clearance of apoptotic cells (ACs) by professional or nonprofessional phagocytes are normal and coordinated processes that ensure controlled cell growth and stress response with nonpathological outcomes. Uptake of ACs by phagocytes is thought to suppress autoimmune responses through the release of anti-inflammatory cytokines such as interleukin-10 (IL-10), transforming growth factor-beta (TGF-beta), and inhibition of proinflammatory cytokines. The production of pro- and anti-inflammatory cytokines by phagocytes is highly regulated as part of an intrinsic mechanism to prevent inflammatory and autoimmune reactions in a physiological state. Production of IL-10 by phagocytes during clearance of ACs is critical to ensuring cellular homeostasis and suppression of autoimmunity. The molecular mechanism whereby IL-10 production is induced by ACs is only beginning to be understood. This review summarizes our recent work in this aspect of an essential physiological and homeostatic process.
摘要
细胞凋亡和专业或非专业吞噬细胞对凋亡细胞 (ACs) 的快速清除是正常且协调的过程，可确保细胞生长和应激反应受到控制，不会导致病理性结果。吞噬细胞摄取 ACs 被认为通过释放抗炎细胞因子（如白细胞介素 10 (IL-10)、转化生长因子-β (TGF-β)）来抑制自身免疫反应，并抑制促炎细胞因子。吞噬细胞产生促炎和抗炎细胞因子受到高度调节，这是一种内在机制的一部分，可防止在生理状态下发生炎症和自身免疫反应。吞噬细胞在清除 ACs 过程中产生 IL-10 对于确保细胞内稳态和抑制自身免疫至关重要。吞噬细胞被 AC 诱导产生 IL-10 的分子机制才刚刚开始被理解。这篇综述总结了我们在这个重要生理和内稳态过程的这一方面的最新工作。
相似文献
1
Regulation of interleukin-10 gene expression in macrophages engulfing apoptotic cells.吞噬凋亡细胞的巨噬细胞中白细胞介素-10 基因表达的调控。
J Interferon Cytokine Res. 2010 Mar;30(3):113-22. doi: 10.1089/jir.2010.0004.
2
Regulation of cytokine production during phagocytosis of apoptotic cells.凋亡细胞吞噬过程中细胞因子产生的调控。
Cell Res. 2006 Feb;16(2):154-61. doi: 10.1038/sj.cr.7310021.
3
Immunological consequences of macrophage-mediated clearance of apoptotic cells.巨噬细胞介导的凋亡细胞清除的免疫学后果。
Cell Cycle. 2005 Feb;4(2):231-4. doi: 10.4161/cc.4.2.1421. Epub 2005 Feb 7.
4
Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.5'-单磷酸腺苷激活的蛋白激酶调节巨噬细胞中白细胞介素-10介导的抗炎信号通路。
J Immunol. 2015 Jan 15;194(2):584-94. doi: 10.4049/jimmunol.1401024. Epub 2014 Dec 15.
5
IL-10-producing macrophages preferentially clear early apoptotic cells.产生白细胞介素-10的巨噬细胞优先清除早期凋亡细胞。
Blood. 2006 Jun 15;107(12):4930-7. doi: 10.1182/blood-2005-10-4144. Epub 2006 Feb 23.
6
Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.凋亡细胞可抑制巨噬细胞中脂多糖诱导的细胞因子和趋化因子的产生以及干扰素反应。
Hum Immunol. 2007 Mar;68(3):156-64. doi: 10.1016/j.humimm.2006.12.008. Epub 2007 Jan 8.
7
8
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.在体外摄取凋亡细胞的巨噬细胞通过涉及转化生长因子-β、前列腺素E2和血小板活化因子的自分泌/旁分泌机制抑制促炎细胞因子的产生。
J Clin Invest. 1998 Feb 15;101(4):890-8. doi: 10.1172/JCI1112.
9
Cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the Mer receptor.胆固醇诱导的凋亡巨噬细胞在吞噬细胞中引发炎症反应，Mer受体可部分减弱这种反应。
J Biol Chem. 2006 Mar 10;281(10):6707-17. doi: 10.1074/jbc.M510579200. Epub 2005 Dec 27.
10
Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance.凋亡细胞在清除过程中触发的抗炎机制。
Front Immunol. 2017 Aug 2;8:909. doi: 10.3389/fimmu.2017.00909. eCollection 2017.
引用本文的文献
1
ECP-induced Apoptosis: How Noninflammatory Cell Death Counterbalances Ischemia/Reperfusion Injury.依前列醇诱导的细胞凋亡：非炎性细胞死亡如何平衡缺血/再灌注损伤。
Transplant Direct. 2025 Sep 2;11(9):e1816. doi: 10.1097/TXD.0000000000001816. eCollection 2025 Sep.
2
The diverse roles of neutrophils from protection to pathogenesis.中性粒细胞从保护到发病机制的多种作用。
Nat Immunol. 2024 Dec;25(12):2209-2219. doi: 10.1038/s41590-024-02006-5. Epub 2024 Nov 20.
3
Cardiac repair after myocardial infarction: A two-sided role of inflammation-mediated.心肌梗死后的心脏修复：炎症介导的双重作用。
Front Cardiovasc Med. 2023 Jan 9;9:1077290. doi: 10.3389/fcvm.2022.1077290. eCollection 2022.
4
Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction.中性粒细胞在心肌梗死后心肌损伤和修复中的作用。
Cells. 2021 Jul 2;10(7):1676. doi: 10.3390/cells10071676.
5
Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities.特异性促分解介质减轻癌症相关炎症：肿瘤相关巨噬细胞的作用和治疗机会。
Front Immunol. 2021 Jun 30;12:702785. doi: 10.3389/fimmu.2021.702785. eCollection 2021.
6
Impact of polyphenols in phagocyte functions.多酚对吞噬细胞功能的影响。
J Inflamm Res. 2019 Aug 21;12:205-217. doi: 10.2147/JIR.S193749. eCollection 2019.
7
Novel Treatment of Experimental Autoimmune Prostatitis by Nanoparticle-Conjugated Autoantigen Peptide T2.T2 抗原肽纳米颗粒偶联物对实验性自身免疫性前列腺炎的新型治疗作用。
Inflammation. 2019 Jun;42(3):1071-1081. doi: 10.1007/s10753-019-00968-5.
8
The interplay between local immune response and Epstein-Barr virus-infected tonsillar cells could lead to viral infection control.局部免疫反应与 Epstein-Barr 病毒感染的扁桃体细胞之间的相互作用可能导致病毒感染得到控制。
Med Microbiol Immunol. 2018 Nov;207(5-6):319-327. doi: 10.1007/s00430-018-0553-2. Epub 2018 Jul 25.
9
Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M.负向调节因子IRAK-M功能受损的小鼠黏膜防御增强且肿瘤负荷降低
EBioMedicine. 2017 Feb;15:36-47. doi: 10.1016/j.ebiom.2016.11.039. Epub 2016 Dec 3.
10
MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1.微小RNA-34a部分通过沉默信息调节因子1负向调控组织巨噬细胞的噬菌作用。
J Immunol. 2016 Feb 1;196(3):1366-75. doi: 10.4049/jimmunol.1401838. Epub 2015 Dec 30.
本文引用的文献
1
The septic shock-associated IL-10 -1082 A > G polymorphism mediates allele-specific transcription via poly(ADP-Ribose) polymerase 1 in macrophages engulfing apoptotic cells.脓毒症休克相关的白细胞介素-10-1082A>G 多态性通过吞噬凋亡细胞的巨噬细胞中的多聚（ADP-核糖）聚合酶 1 介导等位基因特异性转录。
J Immunol. 2010 Apr 1;184(7):3718-24. doi: 10.4049/jimmunol.0903613. Epub 2010 Feb 24.
2
Phagosome maturation: going through the acid test.吞噬体成熟：经受酸性考验
Nat Rev Mol Cell Biol. 2008 Oct;9(10):781-95. doi: 10.1038/nrm2515.
3
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.C1q结合磷脂酰丝氨酸，可能在凋亡细胞识别中作为多配体桥接分子发挥作用。
J Immunol. 2008 Feb 15;180(4):2329-38. doi: 10.4049/jimmunol.180.4.2329.
4
Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.巨噬细胞在吞噬凋亡细胞过程中白细胞介素-10的表达由同源结构域蛋白Pbx1和Prep-1介导。
Immunity. 2007 Dec;27(6):952-64. doi: 10.1016/j.immuni.2007.11.014.
5
Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor.膜磷脂酰丝氨酸受体stabilin-2介导的快速细胞尸体清除
Cell Death Differ. 2008 Jan;15(1):192-201. doi: 10.1038/sj.cdd.4402242. Epub 2007 Oct 26.
6
Identification of Tim4 as a phosphatidylserine receptor.鉴定Tim4为磷脂酰丝氨酸受体。
Nature. 2007 Nov 15;450(7168):435-9. doi: 10.1038/nature06307. Epub 2007 Oct 24.
7
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.BAI1是ELMO/Dock180/Rac模块上游凋亡细胞的吞噬受体。
Nature. 2007 Nov 15;450(7168):430-4. doi: 10.1038/nature06329.
8
Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1.狼疮相关白细胞介素-10启动子单核苷酸多态性的差异表达由聚（ADP-核糖）聚合酶-1介导。
Genes Immun. 2007 Oct;8(7):577-89. doi: 10.1038/sj.gene.6364420. Epub 2007 Aug 16.
9
Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.PARP-1对转录的调控：在致癌作用和炎症中的影响
Curr Med Chem. 2007;14(11):1179-87. doi: 10.2174/092986707780597998.
10
Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription.聚（ADP - 核糖）聚合酶 -1（Parp -1）以序列特异性方式结合于Bcl -6基因座，并参与Bcl -6转录的调控。
Oncogene. 2007 Sep 13;26(42):6244-52. doi: 10.1038/sj.onc.1210434. Epub 2007 Apr 2.
Zotero 插件