Geidel S, Ostermeyer J, Lass M, Geisler M, Kotetishvili N, Aslan H, Boczor S, Kuck K-H
Abteilung für Herzchirurgie, Allgemeines Krankenhaus St. Georg, Hamburg, Germany.
Thorac Cardiovasc Surg. 2006 Mar;54(2):91-5. doi: 10.1055/s-2005-872860.
Data on combined permanent atrial fibrillation (pAF) surgery and coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) are scarce, and the mid- and long-term effects on survival and cardiac rhythm are unknown.
In a prospective analysis 125 patients (Group I: CABG and/or AVR, n = 50; Group II: mitral valve [MV] surgery, n = 75) with pAF (> or = 6 months) underwent either concomitant monopolar (Group I: n = 20; Group II: n = 75) or bipolar (Group I: n = 30) radiofrequency (RF) ablation procedures. Group I patients had a significantly smaller left atrial (LA) size than Group II patients (LA-diameter: 47.7 +/- 4.6 vs. 58.2 +/- 6.1 mm; p < 0.01). Regular follow-up was performed from 3 to 36 months after surgery to assess survival, NYHA-class, and conversion rate to stable sinus rhythm (SR).
Early mortality (< 30 days) of Group I patients was 0% (Group II: 2.7%), cumulative survival at long-term follow-up was 0.95 vs. 0.82 (p = 0.31) and NYHA-class improved significantly in both groups, particularly in cases with stable SR. At follow-up 80% of Group I patients had SR (Group II: 70%). In Group I patients the bipolar approach was associated with significantly shorter ablation procedure times compared to the monopolar procedure (12.1 +/- 3.4 vs. 18.9 +/- 1.6 min; p < 0.05).
Concomitant pAF ablation surgery in CABG and/or AVR is safe and at least as effective as in MV surgery, presumably because severe LA enlargement is exceptionally rare in this group.
关于永久性心房颤动(pAF)手术与冠状动脉旁路移植术(CABG)和/或主动脉瓣置换术(AVR)联合应用的数据稀少,其对生存和心律的中长期影响尚不清楚。
在一项前瞻性分析中,125例患有pAF(≥6个月)的患者(I组:CABG和/或AVR,n = 50;II组:二尖瓣[MV]手术,n = 75)接受了单极(I组:n = 20;II组:n = 75)或双极(I组:n = 30)射频(RF)消融术。I组患者的左心房(LA)大小明显小于II组患者(LA直径:47.7±4.6 vs. 58.2±6.1 mm;p < 0.01)。术后3至36个月进行定期随访,以评估生存率、纽约心脏协会(NYHA)心功能分级以及转为稳定窦性心律(SR)的转化率。
I组患者的早期死亡率(<30天)为0%(II组:2.7%),长期随访时的累积生存率为0.95 vs. 0.82(p = 0.3),两组的NYHA心功能分级均显著改善,尤其是在SR稳定的病例中。随访时,I组80%的患者为SR(II组:70%)。在I组患者中,与单极手术相比,双极手术方法的消融手术时间明显更短(12.1±3.4 vs. 18.9±1.6分钟;p < 0.05)。
CABG和/或AVR术中联合pAF消融手术是安全的,且至少与MV手术一样有效,可能是因为该组中严重LA扩大极为罕见。