缺氧诱导因子-1α（HIF-1α）在维持软骨稳态及骨关节炎发病过程中的作用。
The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis.
作者信息
Pfander David, Swoboda Bernd, Cramer Thorsten
机构信息
Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.
出版信息
Arthritis Res Ther. 2006;8(1):104. doi: 10.1186/ar1894. Epub 2006 Jan 18.
Abstract
As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In recent years, a vast number of papers reporting on the role of hypoxia in cartilage development and disease has been published. It is well established today that the principal mediator of cellular adaptation to hypoxia, the transcription factor hypoxia inducible factor (HIF)-1, is of pivotal importance for survival and growth arrest of chondrocytes during cartilage development as well as energy generation and matrix synthesis of chondrocytes in healthy as well as osteoarthritic cartilage. With this commentary we aim to briefly discuss the recently published literature in this field.
摘要
由于软骨无血管的特性，软骨细胞所处的微环境具有恶劣条件，最显著的是氧气水平极低（缺氧）。近年来，大量关于缺氧在软骨发育和疾病中作用的论文已发表。如今已明确，细胞适应缺氧的主要调节因子——转录因子缺氧诱导因子（HIF）-1，对于软骨发育过程中软骨细胞的存活和生长停滞，以及健康和骨关节炎软骨中软骨细胞的能量生成和基质合成至关重要。通过这篇评论，我们旨在简要讨论该领域最近发表的文献。
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