Wells A, Teria M, Eve T
Process R&D, AstraZeneca, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.
Biochem Soc Trans. 2006 Apr;34(Pt 2):304-8. doi: 10.1042/BST20060304.
Laccases are oxidase enzymes produced by 'white rot' fungi as part of a complex armoury of redox enzymes used to break down lignin--part of the carbon cycle of nature. Laccases alone or in combination with redox co-catalysts have been shown to oxidize xenobiotic compounds under conditions that can be described as 'green'. This paper describes some novel oxidations using the laccase-mediator method and some current limitations to the use of this technology.
漆酶是由“白腐”真菌产生的氧化酶，是用于分解木质素的复杂氧化还原酶库的一部分，而木质素分解是自然界碳循环的一部分。单独的漆酶或与氧化还原共催化剂结合使用时，已被证明能在可称为“绿色”的条件下氧化外源化合物。本文描述了一些使用漆酶-介质法的新型氧化反应以及该技术目前存在的一些局限性。
