Brand Gérard
Laboratoire de Neurosciences, Université de Franche-Comté, Place Leclerc, 25000 Besançon, France.
Neurosci Biobehav Rev. 2006;30(7):908-17. doi: 10.1016/j.neubiorev.2006.01.002. Epub 2006 Mar 20.
For a long time, studies devoted to intranasal chemoreception have separately considered the different systems which coexist in the human nasal cavity, especially the olfactory and trigeminal systems. For the former, the findings have contributed to a better understanding of transduction, perception and the treatment of odors. For the latter, data have contributed to the knowledge of somatosensory innervation into the nose, especially in relation to nociception. During the last two decades, an increasing number of studies focused on interactions occurring between both systems. Indeed, most odorant molecules have the propensity to simultaneously stimulate olfactory and trigeminal systems in the nasal cavity. The interactions between both systems appear complex and take place at peripheral, central or perceptual levels. Studies in neurobiology, electrophysiology, psychophysics or functional imaging contribute to determine how both olfactory and trigeminal systems coexist and how one system could influence the other in the treatment of sensory information. However, several structural, functional and methodological questions remain unsolved in the field of olfactory/trigeminal interactions and deserve further research.
长期以来，致力于鼻内化学感受的研究分别考虑了人类鼻腔中共存的不同系统，尤其是嗅觉和三叉神经感觉系统。对于前者，研究结果有助于更好地理解气味的转导、感知和治疗。对于后者，数据有助于了解鼻子的躯体感觉神经支配，尤其是与伤害感受相关的方面。在过去的二十年中，越来越多的研究聚焦于这两个系统之间发生的相互作用。事实上，大多数气味分子都倾向于同时刺激鼻腔中的嗅觉和三叉神经感觉系统。这两个系统之间的相互作用似乎很复杂，发生在周围、中枢或感知层面。神经生物学、电生理学、心理物理学或功能成像方面的研究有助于确定嗅觉和三叉神经感觉系统如何共存，以及在感觉信息处理过程中一个系统如何影响另一个系统。然而，在嗅觉/三叉神经相互作用领域，仍有几个结构、功能和方法学问题尚未解决，值得进一步研究。
