Balsamo L M, Xu B, Gaillard W D
Department of Neurology, Children's National Medical Center, The George Washington University School of Medicine, Washington, DC 20010, USA.
Neuroimage. 2006 Jul 1;31(3):1306-14. doi: 10.1016/j.neuroimage.2006.01.027. Epub 2006 Mar 20.
We used blood oxygen-dependent (BOLD) fMRI technique at 1.5 T to examine brain regions associated with language comprehension in normally developing children, age 5 to 10 years. Twenty-three children participated in the study using an auditory semantic decision task which varied in task difficulty. Analysis of individual participants' data showed patterns of activation largely consistent with previous neuroimaging findings in adult language processing. Group data analysis also showed a strong left-lateralized pattern of activation that closely resembles those typically observed in adults. In addition, significant activation in the left fusiform gyrus was observed and was associated with task accuracy. This finding suggests that auditory semantic processing in young children may recruit cortical regions associated with word reading in adults prior to the initiation of a semantic category decision, a process which is consistent with patterns of early word recognition process and language development.
我们使用1.5T的血氧依赖性功能磁共振成像（BOLD-fMRI）技术，来检测5至10岁正常发育儿童中与语言理解相关的脑区。23名儿童参与了这项使用听觉语义决策任务的研究，该任务在难度上有所不同。对个体参与者数据的分析显示，激活模式在很大程度上与先前成人语言处理的神经影像学研究结果一致。组数据分析还显示出强烈的左侧激活模式，这与成年人中通常观察到的模式非常相似。此外，在左侧梭状回中观察到显著激活，且其与任务准确性相关。这一发现表明，幼儿的听觉语义处理可能在语义类别决策开始之前，就调用了与成人单词阅读相关的皮质区域，这一过程与早期单词识别过程和语言发展模式是一致的。
