You Tae-Min, Choi Byung-Ho, Zhu Shi-Jiang, Jung Jae-Hyung, Lee Seoung-Ho, Huh Jin-Young, Lee Hyun-Jung, Li Jingxu
Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul and Wonju, South Korea.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jan;103(1):34-7. doi: 10.1016/j.tripleo.2006.01.005. Epub 2006 Apr 21.
The purpose of this study was to evaluate the effects of autogenous bone grafts and platelet-enriched fibrin glue in the treatment of peri-implantitis.
Thirty-six screw-type commercially pure titanium implants with rough acid-etched surfaces were inserted into 6 mongrel dogs 3 months after extraction of mandibular premolars. After 3 months of healing, peri-implantitis was induced by placing gauze and wire around the implants. Once peri-implantitis was created, surgical treatments involving a combination of autogenous bone grafts and platelet-enriched fibrin glue, autogenous bone grafts alone, or a conventional flap procedure only (control) were carried out. Six months later, biopsies of the implant sites were taken and prepared for ground sectioning and analysis.
The amount of reosseointegration was significantly higher in peri-implantitis defects treated with combined autogenous bone grafts and platelet-enriched fibrin glue as compared with the other 2 treatment procedures. A mean bone-to-implant contact of 50.1% was obtained in the peri-implantitis lesions treated with combined autogenous bone grafts and platelet-enriched fibrin glue. The corresponding values for the autogenous bone grafts and control groups were 19.3% and 6.5%, respectively.
The present study demonstrates that surgical treatment involving the combined use of autogenous bone grafts and platelet-enriched fibrin glue might effectively promote reosseointegration in lesions resulting from peri-implantitis.
本研究旨在评估自体骨移植和富血小板纤维蛋白胶在治疗种植体周围炎中的效果。
在下颌前磨牙拔除3个月后，将36颗具有粗糙酸蚀表面的螺旋型商业纯钛种植体植入6只杂种犬体内。愈合3个月后，通过在种植体周围放置纱布和金属丝诱导种植体周围炎。一旦形成种植体周围炎，便进行手术治疗，包括联合使用自体骨移植和富血小板纤维蛋白胶、单独使用自体骨移植或仅采用传统翻瓣手术（对照组）。6个月后，对种植体部位进行活检，并制备磨片进行分析。
与其他两种治疗方法相比，联合使用自体骨移植和富血小板纤维蛋白胶治疗的种植体周围炎缺损处的再骨结合量显著更高。联合使用自体骨移植和富血小板纤维蛋白胶治疗的种植体周围炎病变中，平均骨与种植体接触率为50.1%。自体骨移植组和对照组的相应值分别为19.3%和6.5%。
本研究表明，联合使用自体骨移植和富血小板纤维蛋白胶的手术治疗可能有效促进种植体周围炎所致病变的再骨结合。
